1f2j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:01, 9 August 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1f2j.png|left|200px]]
 
-
{{STRUCTURE_1f2j| PDB=1f2j | SCENE= }}
+
==CRYSTAL STRUCTURE ANALYSIS OF ALDOLASE FROM T. BRUCEI==
 +
<StructureSection load='1f2j' size='340' side='right'caption='[[1f2j]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1f2j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F2J FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f2j OCA], [https://pdbe.org/1f2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f2j RCSB], [https://www.ebi.ac.uk/pdbsum/1f2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f2j ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ALF_TRYBB ALF_TRYBB]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/1f2j_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f2j ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Trypanosomatids, unicellular organisms responsible for several global diseases, contain unique organelles called glycosomes in which the first seven glycolytic enzymes are sequestered. We report the crystal structures of glycosomal fructose-1,6-bisphosphate aldolase from two major tropical pathogens, Trypanosoma brucei and Leishmania mexicana, the causative agents of African sleeping sickness and one form of leishmaniasis, respectively. Unlike mammalian aldolases, the T. brucei and L. mexicana aldolases contain nonameric N-terminal type 2 peroxisomal targeting signals (PTS2s) to direct their import into the glycosome. In both tetrameric trypanosomatid aldolases, the PTS2s from two different subunits form two closely intertwined structures. These "PTS2 dimers", which have very similar conformations in the two aldolase structures, are the first reported conformations of a glycosomal or peroxisomal PTS2, and provide opportunities for the design of trypanocidal compounds.
-
===CRYSTAL STRUCTURE ANALYSIS OF ALDOLASE FROM T. BRUCEI===
+
Structures of type 2 peroxisomal targeting signals in two trypanosomatid aldolases.,Chudzik DM, Michels PA, de Walque S, Hol WG J Mol Biol. 2000 Jul 21;300(4):697-707. PMID:10891264<ref>PMID:10891264</ref>
-
{{ABSTRACT_PUBMED_10891264}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 1f2j" style="background-color:#fffaf0;"></div>
-
[[1f2j]] is a 1 chain structure of [[Aldolase]] with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2J OCA].
+
==See Also==
==See Also==
-
*[[Aldolase|Aldolase]]
+
*[[Aldolase 3D structures|Aldolase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:010891264</ref><references group="xtra"/>
+
__TOC__
-
[[Category: Fructose-bisphosphate aldolase]]
+
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Trypanosoma brucei]]
[[Category: Trypanosoma brucei]]
-
[[Category: Chudzik, D M.]]
+
[[Category: Chudzik DM]]
-
[[Category: Hol, W G.J.]]
+
[[Category: De Walque S]]
-
[[Category: Michels, P A.]]
+
[[Category: Hol WGJ]]
-
[[Category: Walque, S De.]]
+
[[Category: Michels PA]]
-
[[Category: 6 bisphosphate]]
+
-
[[Category: Aldolase]]
+
-
[[Category: Beta barrel]]
+
-
[[Category: Fructose 1]]
+
-
[[Category: Lyase]]
+
-
[[Category: Pts signal]]
+
-
[[Category: Trypanosoma]]
+

Current revision

CRYSTAL STRUCTURE ANALYSIS OF ALDOLASE FROM T. BRUCEI

PDB ID 1f2j

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1f2j"
Personal tools