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1am7

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[[Image:1am7.png|left|200px]]
 
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{{STRUCTURE_1am7| PDB=1am7 | SCENE= }}
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==Lysozyme from bacteriophage lambda==
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<StructureSection load='1am7' size='340' side='right'caption='[[1am7]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===Lysozyme from bacteriophage lambda===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1am7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Lambda Escherichia virus Lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AM7 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9514719}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=TRN:NZ2-TRYPTOPHAN'>TRN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1am7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1am7 OCA], [https://pdbe.org/1am7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1am7 RCSB], [https://www.ebi.ac.uk/pdbsum/1am7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1am7 ProSAT]</span></td></tr>
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[[1am7]] is a 3 chain structure of [[Hen Egg-White (HEW) Lysozyme]] with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AM7 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ENLYS_LAMBD ENLYS_LAMBD] Endolysin with transglycosylase activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.[HAMAP-Rule:MF_04109]<ref>PMID:10556513</ref> <ref>PMID:24113139</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/am/1am7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1am7 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Hen Egg-White (HEW) Lysozyme|Hen Egg-White (HEW) Lysozyme]]
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:009514719</ref><ref group="xtra">PMID:010089351</ref><references group="xtra"/>
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__TOC__
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[[Category: Enterobacteria phage lambda]]
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</StructureSection>
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[[Category: Lysozyme]]
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[[Category: Escherichia virus Lambda]]
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[[Category: Declercq, J P.]]
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[[Category: Large Structures]]
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[[Category: Evrard, C.]]
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[[Category: Declercq JP]]
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[[Category: Fastrez, J.]]
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[[Category: Evrard C]]
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[[Category: Evolution]]
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[[Category: Fastrez J]]
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[[Category: Glycosidase]]
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[[Category: Lysozyme]]
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[[Category: Transglycosylase]]
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Current revision

Lysozyme from bacteriophage lambda

PDB ID 1am7

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