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3b26
From Proteopedia
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| - | [[Image:3b26.png|left|200px]] | ||
| - | + | ==Hsp90 alpha N-terminal domain in complex with an inhibitor Ro1127850== | |
| - | + | <StructureSection load='3b26' size='340' side='right'caption='[[3b26]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3b26]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B26 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B2L:4-(1H,3H-BENZO[DE]ISOCHROMEN-6-YL)-6-METHYLPYRIMIDIN-2-AMINE'>B2L</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b26 OCA], [https://pdbe.org/3b26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b26 RCSB], [https://www.ebi.ac.uk/pdbsum/3b26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b26 ProSAT]</span></td></tr> |
| - | [[3b26]] is a 2 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Heat Shock | + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Fukami TA]] |
| - | [[Category: | + | [[Category: Ono N]] |
Current revision
Hsp90 alpha N-terminal domain in complex with an inhibitor Ro1127850
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