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1kwy
From Proteopedia
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| - | [[Image:1kwy.png|left|200px]] | ||
| - | + | ==Rat mannose protein A complexed with man-a13-man.== | |
| - | + | <StructureSection load='1kwy' size='340' side='right'caption='[[1kwy]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1kwy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KWY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PRD_900112:3alpha-alpha-mannobiose'>PRD_900112</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kwy OCA], [https://pdbe.org/1kwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kwy RCSB], [https://www.ebi.ac.uk/pdbsum/1kwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kwy ProSAT]</span></td></tr> |
| - | [[1kwy]] is a 3 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MBL1_RAT MBL1_RAT] Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kw/1kwy_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kwy ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Mannose-binding protein|Mannose-binding protein]] | *[[Mannose-binding protein|Mannose-binding protein]] | ||
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | < | + | [[Category: Large Structures]] |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Clark | + | [[Category: Clark DA]] |
| - | [[Category: Drickamer | + | [[Category: Drickamer K]] |
| - | [[Category: Feinberg | + | [[Category: Feinberg H]] |
| - | [[Category: Kolatkar | + | [[Category: Kolatkar AR]] |
| - | [[Category: Ng | + | [[Category: Ng KK]] |
| - | [[Category: Park-Snyder | + | [[Category: Park-Snyder S]] |
| - | [[Category: Weis | + | [[Category: Weis WI]] |
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Current revision
Rat mannose protein A complexed with man-a13-man.
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