1g6y

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[[Image:1g6y.png|left|200px]]
 
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{{STRUCTURE_1g6y| PDB=1g6y | SCENE= }}
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==CRYSTAL STRUCTURE OF THE GLOBULAR REGION OF THE PRION PROTEIN URE2 FROM YEAST SACCHAROMYCES CEREVISIAE==
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<StructureSection load='1g6y' size='340' side='right'caption='[[1g6y]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF THE GLOBULAR REGION OF THE PRION PROTIEN URE2 FROM YEAST SACCHAROMYCES CEREVISIAE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1g6y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G6Y FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11342133}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g6y OCA], [https://pdbe.org/1g6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g6y RCSB], [https://www.ebi.ac.uk/pdbsum/1g6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g6y ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1g6y]] is a 2 chain structure of [[Prion]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6Y OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/URE2_YEAST URE2_YEAST] Plays an important role in nitrogen catabolite repression. Down-regulates the expression of many genes involved in nitrogen utilization by inhibiting the GATA transcriptional activators GLN3 and GAT1. Under good nitrogen conditions, binds to the phosphorylated forms of GLN3 and GAT1 and sequesters them in the cytoplasm, preventing transcription of genes expressed upon nitrogen limitation. Is also an atypical glutaredoxin without a catalytical cysteine residue. Has glutathione peroxidase and thiol:disulfide oxidoreductase activities in both native and fibrillar form. Also shows insulin disulfide reductase and dehydroascorbic acid reductase (DHAR) actvites.<ref>PMID:1990286</ref> <ref>PMID:8755910</ref> <ref>PMID:10604478</ref> <ref>PMID:10799523</ref> <ref>PMID:15371425</ref> <ref>PMID:19321443</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/1g6y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g6y ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Prion|Prion]]
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*[[Prion 3D structures|Prion 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011342133</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Belrhali, H.]]
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[[Category: Belrhali H]]
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[[Category: Bousset, L.]]
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[[Category: Bousset L]]
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[[Category: Janin, J.]]
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[[Category: Janin J]]
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[[Category: Melki, R.]]
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[[Category: Melki R]]
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[[Category: Morera, S.]]
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[[Category: Morera S]]
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[[Category: Gst superfamily]]
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[[Category: Structural genomic]]
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Current revision

CRYSTAL STRUCTURE OF THE GLOBULAR REGION OF THE PRION PROTEIN URE2 FROM YEAST SACCHAROMYCES CEREVISIAE

PDB ID 1g6y

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