1m6o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1m6o" [edit=sysop:move=sysop])
Current revision (08:32, 10 April 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1m6o.png|left|200px]]
 
-
{{STRUCTURE_1m6o| PDB=1m6o | SCENE= }}
+
==Crystal Structure of HLA B*4402 in complex with HLA DPA*0201 peptide==
-
 
+
<StructureSection load='1m6o' size='340' side='right'caption='[[1m6o]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
===Crystal Structure of HLA B*4402 in complex with HLA DPA*0201 peptide===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1m6o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M6O FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_12939341}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m6o OCA], [https://pdbe.org/1m6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m6o RCSB], [https://www.ebi.ac.uk/pdbsum/1m6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m6o ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[1m6o]] is a 3 chain structure of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6O OCA].
+
== Disease ==
 +
[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m6/1m6o_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m6o ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
+
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
-
*[[Major histocompatibility complex|Major histocompatibility complex]]
+
*[[MHC 3D structures|MHC 3D structures]]
-
 
+
*[[MHC I 3D structures|MHC I 3D structures]]
-
==Reference==
+
== References ==
-
<ref group="xtra">PMID:012939341</ref><references group="xtra"/>
+
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Brooks, A G.]]
+
[[Category: Large Structures]]
-
[[Category: Clements, C S.]]
+
[[Category: Brooks AG]]
-
[[Category: Ely, L K.]]
+
[[Category: Clements CS]]
-
[[Category: Gorman, J J.]]
+
[[Category: Ely LK]]
-
[[Category: Kjer-Nielsen, L.]]
+
[[Category: Gorman JJ]]
-
[[Category: Koelle, D M.]]
+
[[Category: Kjer-Nielsen L]]
-
[[Category: Lovrecz, G O.]]
+
[[Category: Koelle DM]]
-
[[Category: Lu, L.]]
+
[[Category: Lovrecz GO]]
-
[[Category: Macdonald, W A.]]
+
[[Category: Lu L]]
-
[[Category: McCluskey, J.]]
+
[[Category: Macdonald WA]]
-
[[Category: Mifsud, N A.]]
+
[[Category: McCluskey J]]
-
[[Category: Purcell, A W.]]
+
[[Category: Mifsud NA]]
-
[[Category: Rossjohn, J.]]
+
[[Category: Purcell AW]]
-
[[Category: Williams, D S.]]
+
[[Category: Rossjohn J]]
-
[[Category: Glycoprotein]]
+
[[Category: Williams DS]]
-
[[Category: Immune system]]
+
-
[[Category: Mhc i]]
+

Current revision

Crystal Structure of HLA B*4402 in complex with HLA DPA*0201 peptide

PDB ID 1m6o

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1m6o"
Personal tools