2bl2

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[[Image:2bl2.png|left|200px]]
 
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{{STRUCTURE_2bl2| PDB=2bl2 | SCENE= }}
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==The membrane rotor of the V-type ATPase from Enterococcus hirae==
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<StructureSection load='2bl2' size='340' side='right'caption='[[2bl2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2bl2]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_hirae Enterococcus hirae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BL2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LHG:1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE'>LHG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UMQ:UNDECYL-MALTOSIDE'>UMQ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bl2 OCA], [https://pdbe.org/2bl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bl2 RCSB], [https://www.ebi.ac.uk/pdbsum/2bl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bl2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NTPK_ENTHA NTPK_ENTHA] Involved in ATP-driven sodium extrusion.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bl/2bl2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bl2 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The membrane rotor ring from the vacuolar-type (V-type) sodium ion-pumping adenosine triphosphatase (Na+-ATPase) from Enterococcus hirae consists of 10 NtpK subunits, which are homologs of the 16-kilodalton and 8-kilodalton proteolipids found in other V-ATPases and in F1Fo- or F-ATPases, respectively. Each NtpK subunit has four transmembrane alpha helices, with a sodium ion bound between helices 2 and 4 at a site buried deeply in the membrane that includes the essential residue glutamate-139. This site is probably connected to the membrane surface by two half-channels in subunit NtpI, against which the ring rotates. Symmetry mismatch between the rotor and catalytic domains appears to be an intrinsic feature of both V- and F-ATPases.
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===THE MEMBRANE ROTOR OF THE V-TYPE ATPASE FROM ENTEROCOCCUS HIRAE===
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Structure of the rotor of the V-Type Na+-ATPase from Enterococcus hirae.,Murata T, Yamato I, Kakinuma Y, Leslie AG, Walker JE Science. 2005 Apr 29;308(5722):654-9. Epub 2005 Mar 31. PMID:15802565<ref>PMID:15802565</ref>
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{{ABSTRACT_PUBMED_15802565}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2bl2" style="background-color:#fffaf0;"></div>
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[[2bl2]] is a 10 chain structure of [[ATP synthase]] with sequence from [http://en.wikipedia.org/wiki/Enterococcus_hirae Enterococcus hirae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BL2 OCA].
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==See Also==
==See Also==
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*[[ATP synthase|ATP synthase]]
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*[[ATPase 3D structures|ATPase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015802565</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Enterococcus hirae]]
[[Category: Enterococcus hirae]]
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[[Category: Kakinuma, Y.]]
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[[Category: Large Structures]]
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[[Category: Leslie, A G.W.]]
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[[Category: Kakinuma Y]]
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[[Category: Murata, T.]]
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[[Category: Leslie AGW]]
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[[Category: Walker, J E.]]
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[[Category: Murata T]]
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[[Category: Yamato, I.]]
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[[Category: Walker JE]]
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[[Category: Hydrogen ion transport]]
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[[Category: Yamato I]]
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[[Category: Hydrolase]]
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[[Category: K-ring]]
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[[Category: Membrane rotor]]
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[[Category: Sodium transporter]]
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[[Category: Transmembrane]]
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[[Category: V-type atpase]]
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Current revision

The membrane rotor of the V-type ATPase from Enterococcus hirae

PDB ID 2bl2

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