2a07

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[[Image:2a07.png|left|200px]]
 
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{{STRUCTURE_2a07| PDB=2a07 | SCENE= }}
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==Crystal Structure of Foxp2 bound Specifically to DNA.==
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<StructureSection load='2a07' size='340' side='right'caption='[[2a07]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Crystal Structure of Foxp2 bound Specifically to DNA.===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2a07]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A07 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16407075}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a07 OCA], [https://pdbe.org/2a07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a07 RCSB], [https://www.ebi.ac.uk/pdbsum/2a07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a07 ProSAT]</span></td></tr>
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[[2a07]] is a 10 chain structure of [[Forkhead box protein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A07 OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FOXP2_HUMAN FOXP2_HUMAN] Defects in FOXP2 are the cause of speech-language disorder 1 (SPCH1) [MIM:[https://omim.org/entry/602081 602081]; also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Affected individuals have a severe impairment in the selection and sequencing of fine orofacial movements, which are necessary for articulation. They also show deficits in several facets of language processing (such as the ability to break up words into their constituent phonemes) and grammatical skills.<ref>PMID:11586359</ref> Note=A chromosomal aberration involving FOXP2 is a cause of severe speech and language impairment. Translocation t(5;7)(q22;q31.2).
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== Function ==
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[https://www.uniprot.org/uniprot/FOXP2_HUMAN FOXP2_HUMAN] Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/2a07_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a07 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[FOXP2|FOXP2]]
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*[[FOX 3D structures|FOX 3D structures]]
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*[[Forkhead box protein|Forkhead box protein]]
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== References ==
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*[[Foxp2 bound specifically to DNA|Foxp2 bound specifically to DNA]]
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:016407075</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bates, D L.]]
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[[Category: Large Structures]]
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[[Category: Chen, L.]]
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[[Category: Bates DL]]
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[[Category: Han, A.]]
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[[Category: Chen L]]
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[[Category: Nowick, K.]]
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[[Category: Han A]]
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[[Category: Paabo, S.]]
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[[Category: Nowick K]]
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[[Category: Stroud, J C.]]
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[[Category: Paabo S]]
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[[Category: Tong, H.]]
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[[Category: Stroud JC]]
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[[Category: Wu, Y.]]
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[[Category: Tong H]]
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[[Category: Double-helix]]
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[[Category: Wu Y]]
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[[Category: Forkhead]]
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[[Category: Homodimer]]
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[[Category: Magnesium]]
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[[Category: Monomer]]
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[[Category: Swapping]]
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[[Category: Transcription-dna complex]]
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[[Category: Winged-helix]]
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Current revision

Crystal Structure of Foxp2 bound Specifically to DNA.

PDB ID 2a07

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