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2anl

From Proteopedia

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[[Image:2anl.png|left|200px]]
 
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{{STRUCTURE_2anl| PDB=2anl | SCENE= }}
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==X-ray crystal structure of the aspartic protease plasmepsin 4 from the malarial parasite plasmodium malariae bound to an allophenylnorstatine based inhibitor==
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<StructureSection load='2anl' size='340' side='right'caption='[[2anl]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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===X-ray crystal structure of the aspartic protease plasmepsin 4 from the malarial parasite plasmodium malariae bound to an allophenylnorstatine based inhibitor===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2anl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_malariae Plasmodium malariae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ANL FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16510971}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JE2:(4R)-3-{(2S,3S)-2-HYDROXY-3-[(3-HYDROXY-2-METHYLBENZOYL)AMINO]-4-PHENYLBUTANOYL}-5,5-DIMETHYL-N-(2-METHYLBENZYL)-1,3-THIAZOLIDINE-4-CARBOXAMIDE'>JE2</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2anl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2anl OCA], [https://pdbe.org/2anl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2anl RCSB], [https://www.ebi.ac.uk/pdbsum/2anl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2anl ProSAT]</span></td></tr>
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[[2anl]] is a 2 chain structure of [[Plasmepsin]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_malariae Plasmodium malariae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANL OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O60990_PLAMA O60990_PLAMA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/an/2anl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2anl ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Plasmepsin|Plasmepsin]]
*[[Plasmepsin|Plasmepsin]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:016510971</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Plasmodium malariae]]
[[Category: Plasmodium malariae]]
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[[Category: Agbandje-McKenna, M.]]
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[[Category: Agbandje-McKenna M]]
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[[Category: Clemente, J C.]]
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[[Category: Clemente JC]]
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[[Category: Dame, J B.]]
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[[Category: Dame JB]]
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[[Category: Dunn, B M.]]
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[[Category: Dunn BM]]
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[[Category: Fisher, S Z.]]
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[[Category: Fisher SZ]]
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[[Category: Govindasamy, L.]]
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[[Category: Govindasamy L]]
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[[Category: Hayashi, Y.]]
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[[Category: Hayashi Y]]
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[[Category: Hidaka, K.]]
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[[Category: Hidaka K]]
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[[Category: Kimura, T.]]
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[[Category: Kimura T]]
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[[Category: Kiso, Y.]]
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[[Category: Kiso Y]]
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[[Category: Madabushi, A.]]
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[[Category: Madabushi A]]
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[[Category: McKenna, R.]]
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[[Category: McKenna R]]
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[[Category: Moose, R E.]]
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[[Category: Moose RE]]
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[[Category: Yowell, C A.]]
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[[Category: Yowell CA]]
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[[Category: Aspartic protease]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Plasmepsin 4]]
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[[Category: Plasmodium parasite]]
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Current revision

X-ray crystal structure of the aspartic protease plasmepsin 4 from the malarial parasite plasmodium malariae bound to an allophenylnorstatine based inhibitor

PDB ID 2anl

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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