2d2z

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[[Image:2d2z.png|left|200px]]
 
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{{STRUCTURE_2d2z| PDB=2d2z | SCENE= }}
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==Crystal structure of Soluble Form Of CLIC4==
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<StructureSection load='2d2z' size='340' side='right'caption='[[2d2z]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Crystal structure of Soluble Form Of CLIC4===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2d2z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D2Z FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16581025}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d2z OCA], [https://pdbe.org/2d2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d2z RCSB], [https://www.ebi.ac.uk/pdbsum/2d2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d2z ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2d2z]] is a 3 chain structure of [[Ion channels]] and [[Ion channels (Part II)]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D2Z OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/CLIC4_HUMAN CLIC4_HUMAN] Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).<ref>PMID:12163372</ref> <ref>PMID:14569596</ref> <ref>PMID:16239224</ref> <ref>PMID:18302930</ref> <ref>PMID:19247789</ref> <ref>PMID:16176272</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/2d2z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d2z ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ion channels|Ion channels]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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*[[Ion channels (Part II)|Ion channels (Part II)]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016581025</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Li, D F.]]
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[[Category: Large Structures]]
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[[Category: Li, Y F.]]
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[[Category: Li DF]]
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[[Category: Wang, D C.]]
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[[Category: Li YF]]
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[[Category: Clic4]]
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[[Category: Wang DC]]
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[[Category: Soluble form]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of Soluble Form Of CLIC4

PDB ID 2d2z

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