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3oky
From Proteopedia
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| - | [[Image:3oky.png|left|200px]] | ||
| - | + | ==Plexin A2 in complex with Semaphorin 6A== | |
| - | + | <StructureSection load='3oky' size='340' side='right'caption='[[3oky]], [[Resolution|resolution]] 2.19Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3oky]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OKY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.195Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oky OCA], [https://pdbe.org/3oky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oky RCSB], [https://www.ebi.ac.uk/pdbsum/3oky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oky ProSAT]</span></td></tr> |
| - | [[3oky]] is a 2 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PLXA2_MOUSE PLXA2_MOUSE] Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.<ref>PMID:10520994</ref> <ref>PMID:10781943</ref> <ref>PMID:20877282</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Plexin|Plexin]] | + | *[[Plexin 3D structures|Plexin 3D structures]] |
| - | + | *[[Semaphorin 3D structures|Semaphorin 3D structures]] | |
| - | == | + | == References == |
| - | < | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Bell | + | [[Category: Bell CH]] |
| - | [[Category: Janssen | + | [[Category: Janssen BJC]] |
| - | [[Category: Jones | + | [[Category: Jones EY]] |
| - | [[Category: Robinson | + | [[Category: Robinson RA]] |
| - | [[Category: Siebold | + | [[Category: Siebold C]] |
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Current revision
Plexin A2 in complex with Semaphorin 6A
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