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3hq5

From Proteopedia

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[[Image:3hq5.png|left|200px]]
 
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{{STRUCTURE_3hq5| PDB=3hq5 | SCENE= }}
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==Progesterone Receptor bound to an Alkylpyrrolidine ligand.==
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<StructureSection load='3hq5' size='340' side='right'caption='[[3hq5]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Progesterone Receptor bound to an Alkylpyrrolidine ligand.===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3hq5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HQ5 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19595590}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GKK:2-CHLORO-4-{[(3S)-1-METHYLPYRROLIDIN-3-YL][2-(TRIFLUOROMETHYL)BENZYL]AMINO}BENZONITRILE'>GKK</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hq5 OCA], [https://pdbe.org/3hq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hq5 RCSB], [https://www.ebi.ac.uk/pdbsum/3hq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hq5 ProSAT]</span></td></tr>
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[[3hq5]] is a 2 chain structure of [[Hormone]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQ5 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/3hq5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hq5 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Hormone|Hormone]]
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*[[Progesterone receptor|Progesterone receptor]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019595590</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Madauss, K P.]]
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[[Category: Large Structures]]
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[[Category: Washburn, D G.]]
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[[Category: Madauss KP]]
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[[Category: Williams, S P.]]
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[[Category: Washburn DG]]
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[[Category: Dna-binding]]
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[[Category: Williams SP]]
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[[Category: Hormone binding protein]]
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[[Category: Isopeptide bond]]
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[[Category: Lipid-binding]]
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[[Category: Metal-binding]]
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[[Category: Nuclear receptor]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Pr]]
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[[Category: Progesterone receptor]]
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[[Category: Receptor]]
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[[Category: Steroid-binding]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc-finger]]
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Current revision

Progesterone Receptor bound to an Alkylpyrrolidine ligand.

PDB ID 3hq5

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