3uin

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[[Image:3uin.png|left|200px]]
 
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{{STRUCTURE_3uin| PDB=3uin | SCENE= }}
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==Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2==
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<StructureSection load='3uin' size='340' side='right'caption='[[3uin]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3uin]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UIN FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22194619}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.597&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uin OCA], [https://pdbe.org/3uin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uin RCSB], [https://www.ebi.ac.uk/pdbsum/3uin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uin ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3uin]] is a 4 chain structure of [[SUMO conjugating enzyme Ubc9]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UIN OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/UBC9_HUMAN UBC9_HUMAN] Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation.<ref>PMID:8668529</ref> <ref>PMID:11451954</ref> <ref>PMID:15809060</ref> <ref>PMID:19744555</ref> <ref>PMID:19638400</ref> <ref>PMID:17466333</ref> <ref>PMID:20077568</ref>
==See Also==
==See Also==
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*[[SUMO 3D Structures|SUMO 3D Structures]]
*[[SUMO conjugating enzyme Ubc9|SUMO conjugating enzyme Ubc9]]
*[[SUMO conjugating enzyme Ubc9|SUMO conjugating enzyme Ubc9]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022194619</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Gareau, J R.]]
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[[Category: Large Structures]]
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[[Category: Lima, C D.]]
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[[Category: Gareau JR]]
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[[Category: Reverter, D.]]
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[[Category: Lima CD]]
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[[Category: E3]]
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[[Category: Reverter D]]
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[[Category: Ligase]]
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[[Category: Ligase-isomerase-protein binding complex]]
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[[Category: Nuclear pore complex]]
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[[Category: Ranbp2]]
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[[Category: Sumo]]
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[[Category: Ubc9]]
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Current revision

Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2

PDB ID 3uin

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