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2q9f

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[[Image:2q9f.png|left|200px]]
 
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{{STRUCTURE_2q9f| PDB=2q9f | SCENE= }}
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==Crystal structure of human cytochrome P450 46A1 in complex with cholesterol-3-sulphate==
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<StructureSection load='2q9f' size='340' side='right'caption='[[2q9f]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Crystal structure of human cytochrome P450 46A1 in complex with cholesterol-3-sulphate===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2q9f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q9F FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18621681}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C3S:CHOLEST-5-EN-3-YL+HYDROGEN+SULFATE'>C3S</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9f OCA], [https://pdbe.org/2q9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q9f RCSB], [https://www.ebi.ac.uk/pdbsum/2q9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q9f ProSAT]</span></td></tr>
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[[2q9f]] is a 1 chain structure of [[Cytochrome P450]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9F OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CP46A_HUMAN CP46A_HUMAN] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q9/2q9f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q9f ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cytochrome P450|Cytochrome P450]]
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:018621681</ref><ref group="xtra">PMID:018453684</ref><references group="xtra"/>
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[[Category: Cholesterol 24-hydroxylase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Johnson, E F.]]
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[[Category: Large Structures]]
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[[Category: Mast, N V.]]
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[[Category: Johnson EF]]
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[[Category: Pikuleva, I A.]]
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[[Category: Mast NV]]
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[[Category: Stout, C D.]]
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[[Category: Pikuleva IA]]
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[[Category: White, M A.]]
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[[Category: Stout CD]]
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[[Category: Cholesterol metabolic enzyme]]
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[[Category: White MA]]
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[[Category: Cholesterol-3-sulphate]]
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[[Category: Cyp46a1]]
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[[Category: Heme]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: P450]]
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[[Category: P450 46a1]]
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Current revision

Crystal structure of human cytochrome P450 46A1 in complex with cholesterol-3-sulphate

PDB ID 2q9f

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