2pji
From Proteopedia
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| - | [[Image:2pji.png|left|200px]] | ||
| - | + | ==Solution structure of rhodostomin P48A mutant== | |
| - | + | <StructureSection load='2pji' size='340' side='right'caption='[[2pji]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2pji]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Agkistrodon_rhodostoma Agkistrodon rhodostoma]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xaz 1xaz]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PJI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RHOD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8717 Agkistrodon rhodostoma])</td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pji OCA], [https://pdbe.org/2pji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pji RCSB], [https://www.ebi.ac.uk/pdbsum/2pji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pji ProSAT]</span></td></tr> |
| - | [[2pji]] is a 1 chain structure | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH]] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pj/2pji_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pji ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Disintegrin|Disintegrin]] | *[[Disintegrin|Disintegrin]] | ||
| - | [[Category: | + | __TOC__ |
| - | [[Category: Chuang, W J | + | </StructureSection> |
| - | [[Category: Liu, Y C | + | [[Category: Agkistrodon rhodostoma]] |
| - | [[Category: Shiu, J H | + | [[Category: Large Structures]] |
| + | [[Category: Chuang, W J]] | ||
| + | [[Category: Liu, Y C]] | ||
| + | [[Category: Shiu, J H]] | ||
[[Category: Disintegrin]] | [[Category: Disintegrin]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Rhodostomin]] | [[Category: Rhodostomin]] | ||
Current revision
Solution structure of rhodostomin P48A mutant
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