1fyw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1fyw" [edit=sysop:move=sysop])
Current revision (11:18, 27 March 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1fyw.png|left|200px]]
 
-
{{STRUCTURE_1fyw| PDB=1fyw | SCENE= }}
+
==CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR2==
-
 
+
<StructureSection load='1fyw' size='340' side='right'caption='[[1fyw]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-
===CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR2===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1fyw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FYW FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_11081518}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyw OCA], [https://pdbe.org/1fyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fyw RCSB], [https://www.ebi.ac.uk/pdbsum/1fyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyw ProSAT], [https://www.topsan.org/Proteins/NESGC/1fyw TOPSAN]</span></td></tr>
-
[[1fyw]] is a 1 chain structure of [[Toll-like Receptors]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYW OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TLR2_HUMAN TLR2_HUMAN] Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/1fyw_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fyw ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Toll-like Receptors|Toll-like Receptors]]
+
*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:011081518</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Horng, T.]]
+
[[Category: Large Structures]]
-
[[Category: Manley, J L.]]
+
[[Category: Horng T]]
-
[[Category: Medzhitov, R.]]
+
[[Category: Manley JL]]
-
[[Category: NESG, Northeast Structural Genomics Consortium.]]
+
[[Category: Medzhitov R]]
-
[[Category: Shen, B.]]
+
[[Category: Shen B]]
-
[[Category: Tao, X.]]
+
[[Category: Tao X]]
-
[[Category: Tong, L.]]
+
[[Category: Tong L]]
-
[[Category: Xu, Y.]]
+
[[Category: Xu Y]]
-
[[Category: Beta-alpha-beta fold parallel beta sheet]]
+
-
[[Category: Nesg]]
+
-
[[Category: Northeast structural genomics consortium]]
+
-
[[Category: Protein structure initiative]]
+
-
[[Category: Psi]]
+
-
[[Category: Signaling protein]]
+
-
[[Category: Structural genomic]]
+

Current revision

CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR2

PDB ID 1fyw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fyw"
Personal tools