1a8f

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[[Image:1a8f.png|left|200px]]
 
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{{STRUCTURE_1a8f| PDB=1a8f | SCENE= }}
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==HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE==
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<StructureSection load='1a8f' size='340' side='right'caption='[[1a8f]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1a8f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A8F FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9609685}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8f OCA], [https://pdbe.org/1a8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a8f RCSB], [https://www.ebi.ac.uk/pdbsum/1a8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8f ProSAT]</span></td></tr>
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[[1a8f]] is a 1 chain structure of [[Transferrin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8F OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/1a8f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a8f ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Transferrin|Transferrin]]
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*[[Transferrin 3D structures|Transferrin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:009609685</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Anderson, B F.]]
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[[Category: Large Structures]]
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[[Category: Baker, E N.]]
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[[Category: Anderson BF]]
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[[Category: Baker, H.]]
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[[Category: Baker EN]]
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[[Category: Bewley, M.]]
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[[Category: Baker H]]
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[[Category: Brayer, G D.]]
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[[Category: Bewley M]]
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[[Category: Chen, J.]]
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[[Category: Brayer GD]]
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[[Category: Luo, Y.]]
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[[Category: Chen J]]
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[[Category: Macgillivray, R T.A.]]
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[[Category: Luo Y]]
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[[Category: Mason, A B.]]
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[[Category: Macgillivray RTA]]
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[[Category: Moore, S A.]]
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[[Category: Mason AB]]
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[[Category: Murphy, M E.P.]]
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[[Category: Moore SA]]
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[[Category: Smith, C A.]]
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[[Category: Murphy MEP]]
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[[Category: Wang, Y.]]
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[[Category: Smith CA]]
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[[Category: Woodworth, R C.]]
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[[Category: Wang Y]]
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[[Category: Carbonate]]
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[[Category: Woodworth RC]]
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[[Category: Glycoprotein]]
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[[Category: Iron transport]]
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[[Category: Iron-release]]
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[[Category: Nlobe]]
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[[Category: Transferrin]]
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Current revision

HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE

PDB ID 1a8f

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