1auo

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[[Image:1auo.gif|left|200px]]<br />
 
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<applet load="1auo" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1auo, resolution 1.80&Aring;" />
 
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'''CARBOXYLESTERASE FROM PSEUDOMONAS FLUORESCENS'''<br />
 
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==Overview==
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==CARBOXYLESTERASE FROM PSEUDOMONAS FLUORESCENS==
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BACKGROUND: A group of esterases, classified as carboxylesterases, hydrolyze carboxylic ester bonds with relatively broad substrate, specificity and are useful for stereospecific synthesis and hydrolysis of, esters. One such carboxylesterase from Pseudomonas fluorescens is a, homodimeric enzyme, consisting of 218-residue subunits. It shows a limited, sequence similarity to some members of the alpha/beta hydrolase, superfamily. Although crystal structures of a number of serine esterases, and lipases have been reported, structural information on, carboxylesterases is very limited. This study was undertaken in order to, provide such information and to understand a structural basis for the, substrate specificity of this carboxylesterase. RESULTS: In this study, the crystal structure of ... [[http://ispc.weizmann.ac.il/pmbin/getpm?9438866 (full description)]]
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<StructureSection load='1auo' size='340' side='right'caption='[[1auo]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1auo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AUO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1auo OCA], [https://pdbe.org/1auo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1auo RCSB], [https://www.ebi.ac.uk/pdbsum/1auo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1auo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EST2_PSEFL EST2_PSEFL] Hydrolyzes carboxylic ester bonds with relatively broad substrate specificity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/1auo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1auo ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1AUO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]]. Active as [[http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1]]. Structure known Active Sites: ACA and ACB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AUO OCA]].
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*[[Carboxylesterase 3D structures|Carboxylesterase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of carboxylesterase from Pseudomonas fluorescens, an alpha/beta hydrolase with broad substrate specificity., Kim KK, Song HK, Shin DH, Hwang KY, Choe S, Yoo OJ, Suh SW, Structure. 1997 Dec 15;5(12):1571-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9438866 9438866]
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[[Category: Large Structures]]
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[[Category: Carboxylesterase]]
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[[Category: Pseudomonas fluorescens]]
[[Category: Pseudomonas fluorescens]]
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[[Category: Single protein]]
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[[Category: Kim KK]]
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[[Category: Kim, K.K.]]
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[[Category: Song HK]]
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[[Category: Song, H.K.]]
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[[Category: Suh SW]]
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[[Category: Suh, S.W.]]
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[[Category: hydrolase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:47:58 2007''
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Current revision

CARBOXYLESTERASE FROM PSEUDOMONAS FLUORESCENS

PDB ID 1auo

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