2f11

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:44, 25 October 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2f11.png|left|200px]]
 
-
{{STRUCTURE_2f11| PDB=2f11 | SCENE= }}
+
==Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor==
-
 
+
<StructureSection load='2f11' size='340' side='right'caption='[[2f11]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
-
===Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2f11]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F11 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_020222714}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IEM:5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-6-ISOBUTOXY-4H-PYRAN-2-CARBOXYLIC+ACID'>IEM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f11 OCA], [https://pdbe.org/2f11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f11 RCSB], [https://www.ebi.ac.uk/pdbsum/2f11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f11 ProSAT]</span></td></tr>
-
[[2f11]] is a 1 chain structure of [[Neuraminidase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F11 OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN] Hydrolyzes sialylated compounds.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f11_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f11 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Neuraminidase|Neuraminidase]]
+
*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:020222714</ref><references group="xtra"/>
+
-
[[Category: Exo-alpha-sialidase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Chavas, L M.G.]]
+
[[Category: Large Structures]]
-
[[Category: Dyason, J C.]]
+
[[Category: Chavas LMG]]
-
[[Category: Fusi, P.]]
+
[[Category: Dyason JC]]
-
[[Category: Itzstein, M von.]]
+
[[Category: Fusi P]]
-
[[Category: Kato, R.]]
+
[[Category: Kato R]]
-
[[Category: Mann, M C.]]
+
[[Category: Mann MC]]
-
[[Category: Monti, E.]]
+
[[Category: Monti E]]
-
[[Category: Tettamanti, G.]]
+
[[Category: Tettamanti G]]
-
[[Category: Thomson, R J.]]
+
[[Category: Thomson RJ]]
-
[[Category: Tringali, C.]]
+
[[Category: Tringali C]]
-
[[Category: Venerando, B.]]
+
[[Category: Venerando B]]
-
[[Category: Wakatsuki, S.]]
+
[[Category: Wakatsuki S]]
-
[[Category: Drug design]]
+
[[Category: Von Itzstein M]]
-
[[Category: Hydrolase]]
+
-
[[Category: Influenza virus]]
+
-
[[Category: Neuraminidase]]
+
-
[[Category: Sialidase]]
+

Current revision

Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor

PDB ID 2f11

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2f11"
Personal tools