1xdx

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[[Image:1xdx.png|left|200px]]
 
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{{STRUCTURE_1xdx| PDB=1xdx | SCENE= }}
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==Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1==
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<StructureSection load='1xdx' size='340' side='right'caption='[[1xdx]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xdx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XDX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xdx OCA], [https://pdbe.org/1xdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xdx RCSB], [https://www.ebi.ac.uk/pdbsum/1xdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xdx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O64980_CHLRE O64980_CHLRE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/1xdx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xdx ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tctex1 is a light chain found in both cytoplasmic and flagellar dyneins and is involved in many fundamental cellular activities, including rhodopsin transport within photoreceptors, and may function in the non-Mendelian transmission of t haplotypes in mice. Here, we present the NMR solution structure for the Tctex1 dimer from Chlamydomonas axonemal inner dynein arm I1. Structural comparisons reveal a strong similarity with the LC8 dynein light chain dimer, including formation of a strand-switched beta sheet interface. Analysis of the Tctex1 structure enables the dynein intermediate chain binding site to be identified and suggests a mechanism by which cargo proteins might be attached to this microtubule motor complex. Comparison with the alternate dynein light chain rp3 reveals how the specificity of dynein-cargo interactions mediated by these dynein components is achieved. In addition, this structure provides insight into the consequences of the mutations found in the t haplotype forms of this protein.
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===Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1===
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Solution structure of the Tctex1 dimer reveals a mechanism for dynein-cargo interactions.,Wu H, Maciejewski MW, Takebe S, King SM Structure. 2005 Feb;13(2):213-23. PMID:15698565<ref>PMID:15698565</ref>
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{{ABSTRACT_PUBMED_15698565}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1xdx" style="background-color:#fffaf0;"></div>
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[[1xdx]] is a 2 chain structure of [[Dynein]] with sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDX OCA].
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==See Also==
==See Also==
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*[[Dynein|Dynein]]
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*[[Dynein 3D structures|Dynein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015698565</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Chlamydomonas reinhardtii]]
[[Category: Chlamydomonas reinhardtii]]
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[[Category: King, S M.]]
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[[Category: Large Structures]]
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[[Category: Maciejewski, M W.]]
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[[Category: King SM]]
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[[Category: Takebe, S.]]
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[[Category: Maciejewski MW]]
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[[Category: Wu, H.]]
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[[Category: Takebe S]]
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[[Category: Chlamydomonas flagella]]
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[[Category: Wu H]]
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[[Category: Contractile protein]]
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[[Category: Nmr solution structure]]
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[[Category: Tctex1 dimer]]
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Current revision

Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1

PDB ID 1xdx

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