3i55

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[[Image:3i55.png|left|200px]]
 
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{{STRUCTURE_3i55| PDB=3i55 | SCENE= }}
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==Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit==
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<StructureSection load='3i55' size='340' side='right'caption='[[3i55]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
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===Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3i55]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui] and [https://en.wikipedia.org/wiki/Haloarcula_marismortui_ATCC_43049 Haloarcula marismortui ATCC 43049]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I55 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19738021}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.11&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MA:6-HYDRO-1-METHYLADENOSINE-5-MONOPHOSPHATE'>1MA</scene>, <scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=5AA:N6-DIMETHYL-3-AMINO-ADENOSINE-5-MONOPHOSPHATE'>5AA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYL:MYCALAMIDE+A'>MYL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PO2:HYPOPHOSPHITE'>PO2</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i55 OCA], [https://pdbe.org/3i55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i55 RCSB], [https://www.ebi.ac.uk/pdbsum/3i55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i55 ProSAT]</span></td></tr>
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[[3i55]] is a 31 chain structure of [[Ribosomal protein L10]], [[Ribosomal protein L11]], [[Ribosomal protein L13]], [[Ribosomal protein L14]], [[Ribosomal protein L19]], [[Ribosomal protein L2]], [[Ribosomal protein L21]], [[Ribosomal protein L3]], [[Ribosomal protein L34]], [[Ribosomal protein L4]], [[Ribosomal protein L5]], [[Ribosomal protein L6]] and [[Ribosomal protein L7]] with sequence from [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui] and [http://en.wikipedia.org/wiki/Haloarcula_marismortui_atcc_43049 Haloarcula marismortui atcc 43049]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I55 OCA].
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</table>
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== Function ==
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==See Also==
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[https://www.uniprot.org/uniprot/RL2_HALMA RL2_HALMA] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome (By similarity).[HAMAP-Rule:MF_01320_A]
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*[[Ribosomal protein L10|Ribosomal protein L10]]
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== Evolutionary Conservation ==
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*[[Ribosomal protein L11|Ribosomal protein L11]]
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[[Image:Consurf_key_small.gif|200px|right]]
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*[[Ribosomal protein L13|Ribosomal protein L13]]
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Check<jmol>
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*[[Ribosomal protein L14|Ribosomal protein L14]]
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<jmolCheckbox>
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*[[Ribosomal protein L19|Ribosomal protein L19]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/3i55_consurf.spt"</scriptWhenChecked>
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*[[Ribosomal protein L2|Ribosomal protein L2]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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*[[Ribosomal protein L21|Ribosomal protein L21]]
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<text>to colour the structure by Evolutionary Conservation</text>
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*[[Ribosomal protein L3|Ribosomal protein L3]]
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</jmolCheckbox>
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*[[Ribosomal protein L34|Ribosomal protein L34]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i55 ConSurf].
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*[[Ribosomal protein L4|Ribosomal protein L4]]
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<div style="clear:both"></div>
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*[[Ribosomal protein L5|Ribosomal protein L5]]
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__TOC__
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*[[Ribosomal protein L6|Ribosomal protein L6]]
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</StructureSection>
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*[[Ribosomal protein L7|Ribosomal protein L7]]
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==Reference==
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<ref group="xtra">PMID:019738021</ref><references group="xtra"/>
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[[Category: Haloarcula marismortui]]
[[Category: Haloarcula marismortui]]
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[[Category: Haloarcula marismortui atcc 43049]]
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[[Category: Haloarcula marismortui ATCC 43049]]
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[[Category: Blaha, G.]]
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[[Category: Large Structures]]
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[[Category: Gurel, G.]]
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[[Category: Blaha G]]
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[[Category: Moore, P B.]]
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[[Category: Gurel G]]
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[[Category: Steitz, T A.]]
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[[Category: Moore PB]]
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[[Category: Large ribosomal subunit]]
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[[Category: Steitz TA]]
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[[Category: Metal-binding]]
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[[Category: Mycalamide some]]
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[[Category: Ribonucleoprotein]]
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[[Category: Ribosomal protein]]
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[[Category: Ribosome-antibiotic complex]]
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[[Category: Rna-binding]]
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[[Category: Rrna-binding]]
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[[Category: Trna-binding]]
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[[Category: Zinc-finger]]
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Current revision

Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit

PDB ID 3i55

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