2w4q

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[[Image:2w4q.png|left|200px]]
 
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{{STRUCTURE_2w4q| PDB=2w4q | SCENE= }}
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==Crystal structure of human zinc-binding alcohol dehydrogenase 1 (ZADH1) in ternary complex with NADP and 18beta-glycyrrhetinic acid==
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<StructureSection load='2w4q' size='340' side='right'caption='[[2w4q]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF HUMAN ZINC-BINDING ALCOHOL DEHYDROGENASE 1 (ZADH1) IN TERNARY COMPLEX WITH NADP AND 18BETA-GLYCYRRHETINIC ACID===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2w4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W4Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBW:(3BETA,5BETA,14BETA)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OIC+ACID'>CBW</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[2w4q]] is a 1 chain structure of [[Alcohol dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4Q OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4q OCA], [https://pdbe.org/2w4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w4q RCSB], [https://www.ebi.ac.uk/pdbsum/2w4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTGR2_HUMAN PTGR2_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).<ref>PMID:19000823</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/2w4q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w4q ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Alcohol dehydrogenase|Alcohol dehydrogenase]]
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*[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]]
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[[Category: 15-oxoprostaglandin 13-oxidase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Edwards, A.]]
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[[Category: Bountra C]]
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[[Category: Niesen, F.]]
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[[Category: Edwards A]]
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[[Category: Oppermann, U.]]
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[[Category: Niesen F]]
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[[Category: Picaud, S.]]
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[[Category: Oppermann U]]
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[[Category: Shafqat, N.]]
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[[Category: Picaud S]]
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[[Category: Ugochukwu, E.]]
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[[Category: Shafqat N]]
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[[Category: Weigelt, J.]]
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[[Category: Ugochukwu E]]
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[[Category: Yue, W W.]]
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[[Category: Weigelt J]]
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[[Category: 15-oxoprostalglandin]]
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[[Category: Yue WW]]
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[[Category: Medium-chain dehydrogenase/reductase]]
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[[Category: Nadp]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of human zinc-binding alcohol dehydrogenase 1 (ZADH1) in ternary complex with NADP and 18beta-glycyrrhetinic acid

PDB ID 2w4q

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