3tuy

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[[Image:3tuy.png|left|200px]]
 
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{{STRUCTURE_3tuy| PDB=3tuy | SCENE= }}
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==Phosphorylated Light Chain Domain of Scallop smooth Muscle Myosin==
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<StructureSection load='3tuy' size='340' side='right'caption='[[3tuy]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tuy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Placopecten_magellanicus Placopecten magellanicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TUY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.498&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tuy OCA], [https://pdbe.org/3tuy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tuy RCSB], [https://www.ebi.ac.uk/pdbsum/3tuy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tuy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q26080_PLAMG Q26080_PLAMG]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have determined the crystal structure of a phosphorylated smooth-muscle myosin light chain domain (LCD). This reconstituted LCD is of a sea scallop catch muscle myosin with its phosphorylatable regulatory light chain (RLC SmoA). In the crystal structure, Arg(16), an arginine residue that is present in this isoform but not in vertebrate smooth-muscle RLC, stabilizes the phosphorylation site. This arginine interacts with the carbonyl group of the phosphorylation-site serine in the unphosphorylated LCD (determined previously), and with the phosphate group when the serine is phosphorylated. However, the overall conformation of the LCD is essentially unchanged upon phosphorylation. This result provides additional evidence that phosphorylation of the RLC is unlikely to act as an on-switch in regulation of scallop catch muscle myosin.
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===Phosphorylated Light Chain Domain of Scallop smooth Muscle Myosin===
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Crystal structure of a phosphorylated light chain domain of scallop smooth-muscle Myosin.,Senthil Kumar VS, O'Neall-Hennessey E, Reshetnikova L, Brown JH, Robinson H, Szent-Gyorgyi AG, Cohen C Biophys J. 2011 Nov 2;101(9):2185-9. Epub 2011 Nov 1. PMID:22067157<ref>PMID:22067157</ref>
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{{ABSTRACT_PUBMED_22067157}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3tuy" style="background-color:#fffaf0;"></div>
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[[3tuy]] is a 6 chain structure of [[Myosin]] with sequence from [http://en.wikipedia.org/wiki/Placopecten_magellanicus Placopecten magellanicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TUY OCA].
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==See Also==
==See Also==
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*[[Myosin|Myosin]]
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*[[Myosin 3D Structures|Myosin 3D Structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022067157</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Placopecten magellanicus]]
[[Category: Placopecten magellanicus]]
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[[Category: Brown, J H.]]
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[[Category: Brown JH]]
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[[Category: Cohen, C.]]
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[[Category: Cohen C]]
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[[Category: Kumar, V S.S.]]
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[[Category: Kumar VSS]]
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[[Category: Neall-hennessey, E O.]]
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[[Category: O'Neall-hennessey E]]
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[[Category: Reshetnikova, L.]]
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[[Category: Reshetnikova L]]
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[[Category: Robinson, H.]]
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[[Category: Robinson H]]
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[[Category: Szent-Gyorgyi, A G.]]
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[[Category: Szent-Gyorgyi AG]]
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[[Category: Alpha helical]]
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[[Category: Muscle contraction]]
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[[Category: Protein binding]]
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[[Category: Regulation]]
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[[Category: Smooth muscle]]
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[[Category: Structural protein]]
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Current revision

Phosphorylated Light Chain Domain of Scallop smooth Muscle Myosin

PDB ID 3tuy

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