1dj7

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[[Image:1dj7.png|left|200px]]
 
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{{STRUCTURE_1dj7| PDB=1dj7 | SCENE= }}
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==CRYSTAL STRUCTURE OF FERREDOXIN THIOREDOXIN REDUCTASE==
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<StructureSection load='1dj7' size='340' side='right'caption='[[1dj7]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1dj7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechocystis_sp._PCC_6803 Synechocystis sp. PCC 6803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DJ7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dj7 OCA], [https://pdbe.org/1dj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dj7 RCSB], [https://www.ebi.ac.uk/pdbsum/1dj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dj7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FTRC_SYNY3 FTRC_SYNY3] Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.<ref>PMID:10649999</ref> <ref>PMID:14769790</ref> <ref>PMID:17611542</ref> <ref>PMID:19908864</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dj/1dj7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dj7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Light generates reducing equivalents in chloroplasts that are used not only for carbon reduction, but also for the regulation of the activity of chloroplast enzymes by reduction of regulatory disulfides via the ferredoxin:thioredoxin reductase (FTR) system. FTR, the key electron/thiol transducer enzyme in this pathway, is unique in that it can reduce disulfides by an iron-sulfur cluster, a property that is explained by the tight contact of its active-site disulfide and the iron-sulfur center. The thin, flat FTR molecule makes the two-electron reduction possible by forming on one side a mixed disulfide with thioredoxin and by providing on the opposite side access to ferredoxin for delivering electrons.
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===CRYSTAL STRUCTURE OF FERREDOXIN THIOREDOXIN REDUCTASE===
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Redox signaling in chloroplasts: cleavage of disulfides by an iron-sulfur cluster.,Dai S, Schwendtmayer C, Schurmann P, Ramaswamy S, Eklund H Science. 2000 Jan 28;287(5453):655-8. PMID:10649999<ref>PMID:10649999</ref>
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{{ABSTRACT_PUBMED_10649999}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1dj7" style="background-color:#fffaf0;"></div>
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[[1dj7]] is a 2 chain structure of [[Ferredoxin thioredoxin reductase]] with sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DJ7 OCA].
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==See Also==
==See Also==
*[[Ferredoxin thioredoxin reductase|Ferredoxin thioredoxin reductase]]
*[[Ferredoxin thioredoxin reductase|Ferredoxin thioredoxin reductase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:010649999</ref><references group="xtra"/>
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__TOC__
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[[Category: Synechocystis sp.]]
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</StructureSection>
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[[Category: Dai, S.]]
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[[Category: Large Structures]]
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[[Category: Eklund, H.]]
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[[Category: Synechocystis sp. PCC 6803]]
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[[Category: Ramaswamy, S.]]
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[[Category: Dai S]]
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[[Category: Schurmann, P.]]
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[[Category: Eklund H]]
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[[Category: Schwendtmayer, C.]]
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[[Category: Ramaswamy S]]
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[[Category: 4fe-4s cluster binding fold with cxcx16cxcx8cxc binding motif]]
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[[Category: Schurmann P]]
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[[Category: Electron transport]]
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[[Category: Schwendtmayer C]]

Current revision

CRYSTAL STRUCTURE OF FERREDOXIN THIOREDOXIN REDUCTASE

PDB ID 1dj7

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