1jsh

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[[Image:1jsh.png|left|200px]]
 
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{{STRUCTURE_1jsh| PDB=1jsh | SCENE= }}
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==CRYSTAL STRUCTURE OF H9 HAEMAGGLUTININ COMPLEXED WITH LSTA RECEPTOR ANALOG==
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<StructureSection load='1jsh' size='340' side='right'caption='[[1jsh]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF H9 HAEMAGGLUTININ COMPLEXED WITH LSTA RECEPTOR ANALOG===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jsh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/swine/Hong_Kong/9/98(H9N2)) Influenza A virus (A/swine/Hong Kong/9/98(H9N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JSH FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11562490}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jsh OCA], [https://pdbe.org/1jsh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jsh RCSB], [https://www.ebi.ac.uk/pdbsum/1jsh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jsh ProSAT]</span></td></tr>
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[[1jsh]] is a 2 chain structure of [[Hemagglutinin]] with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/swine/hong_kong/9/98(h9n2)) Influenza a virus (a/swine/hong kong/9/98(h9n2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSH OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q91CD4_9INFA Q91CD4_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013828_004_327643]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/1jsh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jsh ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Hemagglutinin|Hemagglutinin]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011562490</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Ha, Y.]]
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[[Category: Ha Y]]
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[[Category: Skehel, J J.]]
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[[Category: Skehel JJ]]
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[[Category: Stevens, D J.]]
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[[Category: Stevens DJ]]
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[[Category: Wiley, D C.]]
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[[Category: Wiley DC]]
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[[Category: Fusion protein]]
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[[Category: Influenza]]
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[[Category: Receptor complex]]
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[[Category: Viral protein]]
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Current revision

CRYSTAL STRUCTURE OF H9 HAEMAGGLUTININ COMPLEXED WITH LSTA RECEPTOR ANALOG

PDB ID 1jsh

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