2d7e

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[[Image:2d7e.png|left|200px]]
 
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{{STRUCTURE_2d7e| PDB=2d7e | SCENE= }}
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==Crystal structure of N-terminal domain of PriA from E.coli==
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<StructureSection load='2d7e' size='340' side='right'caption='[[2d7e]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal structure of N-terminal domain of PriA from E.coli===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2d7e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D7E FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16226927}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d7e OCA], [https://pdbe.org/2d7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d7e RCSB], [https://www.ebi.ac.uk/pdbsum/2d7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d7e ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2d7e]] is a 4 chain structure of [[Helicase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D7E OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/PRIA_ECOLI PRIA_ECOLI] Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. Is also involved in initiation of normal DNA replication in various plasmids and phages. Binds to branched DNA structures that resemble D-loops or to the primosome assembly site (PAS). Binds to DNA in two distinct modes, either dependent on or independent of the 3' terminus recognition.<ref>PMID:2825188</ref> <ref>PMID:8366072</ref> <ref>PMID:10356325</ref> <ref>PMID:10956036</ref> <ref>PMID:11929519</ref> <ref>PMID:12622722</ref> <ref>PMID:12917421</ref> <ref>PMID:15576682</ref> <ref>PMID:17483094</ref> <ref>PMID:23264623</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d7/2d7e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d7e ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Helicase|Helicase]]
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*[[Helicase 3D structures|Helicase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016226927</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Kohda, D.]]
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[[Category: Large Structures]]
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[[Category: Maenaka, K.]]
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[[Category: Kohda D]]
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[[Category: Masai, H.]]
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[[Category: Maenaka K]]
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[[Category: Ose, T.]]
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[[Category: Masai H]]
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[[Category: Sasaki, K.]]
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[[Category: Ose T]]
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[[Category: Hydrolase]]
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[[Category: Sasaki K]]
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[[Category: Inter-twined]]
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Current revision

Crystal structure of N-terminal domain of PriA from E.coli

PDB ID 2d7e

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