This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1hml

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:33, 27 March 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1hml.png|left|200px]]
 
-
{{STRUCTURE_1hml| PDB=1hml | SCENE= }}
+
==ALPHA_LACTALBUMIN POSSESSES A DISTINCT ZINC BINDING SITE==
-
 
+
<StructureSection load='1hml' size='340' side='right'caption='[[1hml]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-
===ALPHA_LACTALBUMIN POSSESSES A DISTINCT ZINC BINDING SITE===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1hml]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HML FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_8366079}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hml OCA], [https://pdbe.org/1hml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hml RCSB], [https://www.ebi.ac.uk/pdbsum/1hml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hml ProSAT]</span></td></tr>
-
[[1hml]] is a 1 chain structure of [[Lactalbumin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HML OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/LALBA_HUMAN LALBA_HUMAN] Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hm/1hml_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hml ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Lactalbumin|Lactalbumin]]
+
*[[Alpha-lactalbumin|Alpha-lactalbumin]]
-
 
+
*[[Alpha-lactalbumin 3D structures|Alpha-lactalbumin 3D structures]]
-
==Reference==
+
__TOC__
-
<ref group="xtra">PMID:008366079</ref><references group="xtra"/>
+
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Lactose synthase]]
+
[[Category: Large Structures]]
-
[[Category: Acharya, K R.]]
+
[[Category: Acharya KR]]
-
[[Category: Ren, J.]]
+
[[Category: Ren J]]
-
[[Category: Stuart, D I.]]
+
[[Category: Stuart DI]]
-
[[Category: Calcium-binding protein]]
+

Current revision

ALPHA_LACTALBUMIN POSSESSES A DISTINCT ZINC BINDING SITE

PDB ID 1hml

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1hml"
Personal tools