2ebw

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[[Image:2ebw.png|left|200px]]
 
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{{STRUCTURE_2ebw| PDB=2ebw | SCENE= }}
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==Solution structure of the BRCT domain from human DNA repair protein REV1==
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<StructureSection load='2ebw' size='340' side='right'caption='[[2ebw]]' scene=''>
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===Solution structure of the BRCT domain from human DNA repair protein REV1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ebw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EBW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ebw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ebw OCA], [https://pdbe.org/2ebw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ebw RCSB], [https://www.ebi.ac.uk/pdbsum/2ebw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ebw ProSAT], [https://www.topsan.org/Proteins/RSGI/2ebw TOPSAN]</span></td></tr>
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[[2ebw]] is a 1 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EBW OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/REV1_HUMAN REV1_HUMAN] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.<ref>PMID:10536157</ref> <ref>PMID:10760286</ref> <ref>PMID:11278384</ref> <ref>PMID:11485998</ref> <ref>PMID:22266823</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/2ebw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ebw ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA polymerase|DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hayashi, F.]]
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[[Category: Large Structures]]
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[[Category: Nagashima, T.]]
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[[Category: Hayashi F]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Nagashima T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: A/b/a 3 layer]]
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[[Category: Dna polymerase zeta]]
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[[Category: Dna replication]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Parallel beta-sheet]]
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[[Category: Pcna]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Tl]]
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[[Category: Transferase]]
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[[Category: Translession synthesis]]
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Current revision

Solution structure of the BRCT domain from human DNA repair protein REV1

PDB ID 2ebw

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