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1d9d

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[[Image:1d9d.png|left|200px]]
 
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{{STRUCTURE_1d9d| PDB=1d9d | SCENE= }}
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==CRYSTALL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH SHORT DNA FRAGMENT CARRYING 2'-0-AMINOPROPYL-RNA MODIFICATIONS 5'-D(TCG)-AP(AUC)-3'==
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<StructureSection load='1d9d' size='340' side='right'caption='[[1d9d]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
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===CRYSTALL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH SHORT DNA FRAGMENT CARRYING 2'-0-AMINOPROPYL-RNA MODIFICATIONS 5'-D(TCG)-AP(AUC)-3'===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1d9d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D9D FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10588690}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C31:2-O-3-AMINOPROPYL+CYTIDINE-5-MONOPHOSPHATE'>C31</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=U31:2-O-3-AMINOPROPYL+2-DEOXYURIDINE-5-MONOPHOSPHATE'>U31</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9d OCA], [https://pdbe.org/1d9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d9d RCSB], [https://www.ebi.ac.uk/pdbsum/1d9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d9d ProSAT]</span></td></tr>
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[[1d9d]] is a 2 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D9D OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPO1_ECOLI DPO1_ECOLI] In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/1d9d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d9d ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA polymerase|DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010588690</ref><references group="xtra"/>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Cook, P D.]]
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[[Category: Large Structures]]
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[[Category: Egli, M.]]
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[[Category: Cook PD]]
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[[Category: Manoharan, M.]]
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[[Category: Egli M]]
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[[Category: Minasov, G.]]
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[[Category: Manoharan M]]
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[[Category: Simons, A M.]]
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[[Category: Minasov G]]
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[[Category: Teplova, M.]]
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[[Category: Simons AM]]
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[[Category: Tereshko, V.]]
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[[Category: Teplova M]]
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[[Category: Wallace, S T.]]
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[[Category: Tereshko V]]
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[[Category: 2'-o-aminopropyl nucleotide]]
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[[Category: Wallace ST]]
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[[Category: Klenow fragment]]
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[[Category: Rna complex]]
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[[Category: Transferase-dna]]
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[[Category: Transferase/dna]]
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Current revision

CRYSTALL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH SHORT DNA FRAGMENT CARRYING 2'-0-AMINOPROPYL-RNA MODIFICATIONS 5'-D(TCG)-AP(AUC)-3'

PDB ID 1d9d

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