2avt
From Proteopedia
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| - | [[Image:2avt.png|left|200px]] | ||
| - | + | ==Crystal structure of the beta subunit from DNA polymerase of Streptococcus pyogenes== | |
| - | + | <StructureSection load='2avt' size='340' side='right'caption='[[2avt]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2avt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AVT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2avt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2avt OCA], [https://pdbe.org/2avt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2avt RCSB], [https://www.ebi.ac.uk/pdbsum/2avt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2avt ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2avt]] is a 2 chain structure | + | == Function == |
| + | [https://www.uniprot.org/uniprot/Q9EVR1_STRPY Q9EVR1_STRPY] Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.[ARBA:ARBA00002266] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/av/2avt_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2avt ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[DNA polymerase|DNA polymerase]] | + | *[[DNA polymerase 3D structures|DNA polymerase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | < | + | [[Category: Large Structures]] |
[[Category: Streptococcus pyogenes]] | [[Category: Streptococcus pyogenes]] | ||
| - | [[Category: Argiriadi | + | [[Category: Argiriadi MA]] |
| - | [[Category: Bruck | + | [[Category: Bruck I]] |
| - | [[Category: Goedken | + | [[Category: Goedken ER]] |
| - | [[Category: Kuriyan | + | [[Category: Kuriyan J]] |
| - | [[Category: | + | [[Category: O'donnell M]] |
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Current revision
Crystal structure of the beta subunit from DNA polymerase of Streptococcus pyogenes
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