2v6o

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[[Image:2v6o.png|left|200px]]
 
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{{STRUCTURE_2v6o| PDB=2v6o | SCENE= }}
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==Structure of Schistosoma mansoni Thioredoxin-Glutathione Reductase (SmTGR)==
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<StructureSection load='2v6o' size='340' side='right'caption='[[2v6o]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2v6o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V6O FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v6o OCA], [https://pdbe.org/2v6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v6o RCSB], [https://www.ebi.ac.uk/pdbsum/2v6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v6o ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q962Y6_SCHMA Q962Y6_SCHMA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v6/2v6o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v6o ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Thioredoxin glutathione reductase (TGR) is a key flavoenzyme expressed by schistosomes that bridges two detoxification pathways crucial for the parasite survival in the host's organism. In this article we report the crystal structure (at 2.2 A resolution) of TGR from Schistosoma mansoni (SmTGR), deleted in the last two residues. The structure reveals the peculiar architecture of this chimeric enzyme: the small Glutaredoxin (Grx) domain at the N-terminus is joined to the large thioredoxin reductase (TR) one via an extended complementary surface, involving residues not conserved in the Grx superfamily; the TR domain interacts with an identical partner via its C-terminal domain, forming a dimer with a twisted "W" shape. Although lacking the penultimate Selenocysteine residue (Sec), the enzyme is still able to reduce oxidized glutathione. These data update the interpretation of the interdomain communication in TGR enzymes. The possible function of this enzyme in pathogenic parasites is discussed.
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===STRUCTURE OF SCHISTOSOMA MANSONI THIOREDOXIN-GLUTATHIONE REDUCTASE (SMTGR)===
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Glutathione reductase and thioredoxin reductase at the crossroad: the structure of Schistosoma mansoni thioredoxin glutathione reductase.,Angelucci F, Miele AE, Boumis G, Dimastrogiovanni D, Brunori M, Bellelli A Proteins. 2008 Aug 15;72(3):936-45. PMID:18300227<ref>PMID:18300227</ref>
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{{ABSTRACT_PUBMED_18300227}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2v6o" style="background-color:#fffaf0;"></div>
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[[2v6o]] is a 1 chain structure of [[Thioredoxin Glutathione Reductase]] with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V6O OCA].
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==See Also==
==See Also==
*[[Thioredoxin Glutathione Reductase|Thioredoxin Glutathione Reductase]]
*[[Thioredoxin Glutathione Reductase|Thioredoxin Glutathione Reductase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018300227</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Schistosoma mansoni]]
[[Category: Schistosoma mansoni]]
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[[Category: Thioredoxin-disulfide reductase]]
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[[Category: Angelucci F]]
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[[Category: Angelucci, F.]]
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[[Category: Bellelli A]]
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[[Category: Bellelli, A.]]
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[[Category: Boumis G]]
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[[Category: Boumis, G.]]
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[[Category: Brunori M]]
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[[Category: Brunori, M.]]
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[[Category: Dimastrogiovanni D]]
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[[Category: Dimastrogiovanni, D.]]
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[[Category: Miele AE]]
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[[Category: Miele, A E.]]
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[[Category: Chimeric enzyme]]
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[[Category: Fad]]
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[[Category: Flavoprotein]]
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[[Category: Oxidoreductase]]
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[[Category: Redox-active center]]
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[[Category: Thiol-mediated detoxification pathway]]
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Current revision

Structure of Schistosoma mansoni Thioredoxin-Glutathione Reductase (SmTGR)

PDB ID 2v6o

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