1xuq

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[[Image:1xuq.png|left|200px]]
 
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{{STRUCTURE_1xuq| PDB=1xuq | SCENE= }}
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==Crystal Structure of SodA-1 (BA4499) from Bacillus anthracis at 1.8A Resolution.==
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<StructureSection load='1xuq' size='340' side='right'caption='[[1xuq]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xuq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XUQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xuq OCA], [https://pdbe.org/1xuq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xuq RCSB], [https://www.ebi.ac.uk/pdbsum/1xuq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xuq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SODM1_BACAN SODM1_BACAN] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xu/1xuq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xuq ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The BA4499 and BA5696 genes of Bacillus anthracis encode proteins homologous to manganese superoxide dismutase, suggesting that this organism has an expanded repertoire of antioxidant proteins. Differences in metal specificity and quaternary structure between the dismutases of prokaryotes and higher eukaryotes may be exploited in the development of therapeutic antibacterial compounds. Here, the crystal structure of two Mn superoxide dismutases from B. anthracis solved to high resolution are reported. Comparison of their structures reveals that a highly conserved residue near the active centre is substituted in one of the proteins and that this is a characteristic feature of superoxide dismutases from the B. cereus/B. anthracis/B. thuringiensis group of organisms.
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===Crystal Structure of SodA-1 (BA4499) from Bacillus anthracis at 1.8A Resolution.===
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Structures of two superoxide dismutases from Bacillus anthracis reveal a novel active centre.,Boucher IW, Kalliomaa AK, Levdikov VM, Blagova EV, Fogg MJ, Brannigan JA, Wilson KS, Wilkinson AJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jul 1;61(Pt, 7):621-4. Epub 2005 Jun 15. PMID:16511113<ref>PMID:16511113</ref>
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{{ABSTRACT_PUBMED_16511113}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1xuq" style="background-color:#fffaf0;"></div>
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[[1xuq]] is a 2 chain structure of [[Superoxide Dismutase]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUQ OCA].
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==See Also==
==See Also==
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*[[Superoxide Dismutase|Superoxide Dismutase]]
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*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016511113</ref><references group="xtra"/>
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__TOC__
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[[Category: Bacillus anthracis]]
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</StructureSection>
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[[Category: Superoxide dismutase]]
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[[Category: Blagova, E V.]]
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[[Category: Boucher, I W.]]
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[[Category: Brannigan, J A.]]
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[[Category: Fogg, M J.]]
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[[Category: Levdikov, V M.]]
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[[Category: Wilkinson, A J.]]
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[[Category: Wilson, K S.]]
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[[Category: Ba4499]]
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[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
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[[Category: Oxidoreductase]]
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[[Category: Large Structures]]
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[[Category: Soda-1]]
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[[Category: Blagova EV]]
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[[Category: Spine]]
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[[Category: Boucher IW]]
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[[Category: Superoxide dismutase]]
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[[Category: Brannigan JA]]
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[[Category: Fogg MJ]]
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[[Category: Levdikov VM]]
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[[Category: Wilkinson AJ]]
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[[Category: Wilson KS]]

Current revision

Crystal Structure of SodA-1 (BA4499) from Bacillus anthracis at 1.8A Resolution.

PDB ID 1xuq

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