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3hr4

From Proteopedia

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[[Image:3hr4.png|left|200px]]
 
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{{STRUCTURE_3hr4| PDB=3hr4 | SCENE= }}
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==Human iNOS Reductase and Calmodulin Complex==
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<StructureSection load='3hr4' size='340' side='right'caption='[[3hr4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Human iNOS Reductase and Calmodulin Complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3hr4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HR4 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_019737939}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hr4 OCA], [https://pdbe.org/3hr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hr4 RCSB], [https://www.ebi.ac.uk/pdbsum/3hr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hr4 ProSAT]</span></td></tr>
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[[3hr4]] is a 8 chain structure of [[Calmodulin]] and [[Nitric Oxide Synthase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HR4 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NOS2_HUMAN NOS2_HUMAN] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hr/3hr4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hr4 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Calmodulin|Calmodulin]]
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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*[[Nitric Oxide Synthase|Nitric Oxide Synthase]]
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*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:019737939</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Nitric-oxide synthase]]
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[[Category: Large Structures]]
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[[Category: Iyanaki, T.]]
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[[Category: Iyanaki T]]
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[[Category: Kim, J J.K.]]
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[[Category: Kim JJK]]
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[[Category: Misra, I.]]
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[[Category: Misra I]]
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[[Category: Xia, C.]]
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[[Category: Xia C]]
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[[Category: Calmodulin]]
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[[Category: Calmodulin-binding]]
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[[Category: Fad]]
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[[Category: Fmn]]
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[[Category: Heme]]
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[[Category: Inducible nitric oxide synthase]]
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[[Category: Ino]]
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[[Category: Iron]]
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[[Category: Isopeptide bond]]
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[[Category: Metal-binding]]
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[[Category: Methylation]]
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[[Category: Nadp]]
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[[Category: No]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-metal binding protein complex]]
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[[Category: Phosphoprotein]]
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Current revision

Human iNOS Reductase and Calmodulin Complex

PDB ID 3hr4

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