3pc8

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[[Image:3pc8.png|left|200px]]
 
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{{STRUCTURE_3pc8| PDB=3pc8 | SCENE= }}
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==X-ray crystal structure of the heterodimeric complex of XRCC1 and DNA ligase III-alpha BRCT domains.==
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<StructureSection load='3pc8' size='340' side='right'caption='[[3pc8]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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===X-ray crystal structure of the heterodimeric complex of XRCC1 and DNA ligase III-alpha BRCT domains.===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pc8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PC8 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21652643}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pc8 OCA], [https://pdbe.org/3pc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pc8 RCSB], [https://www.ebi.ac.uk/pdbsum/3pc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pc8 ProSAT]</span></td></tr>
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[[3pc8]] is a 4 chain structure of [[DNA ligase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PC8 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/XRCC1_MOUSE XRCC1_MOUSE] Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
==See Also==
==See Also==
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*[[DNA ligase|DNA ligase]]
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*[[DNA ligase 3D structures|DNA ligase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:021652643</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Cuneo, M J.]]
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[[Category: Cuneo MJ]]
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[[Category: Krahn, J M.]]
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[[Category: Krahn JM]]
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[[Category: London, R E.]]
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[[Category: London RE]]
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[[Category: Brct domain]]
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[[Category: Dna binding protein - ligase complex]]
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[[Category: Dna binding protein-ligase complex]]
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[[Category: Dna repair]]
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[[Category: Protein:protein interaction]]
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Current revision

X-ray crystal structure of the heterodimeric complex of XRCC1 and DNA ligase III-alpha BRCT domains.

PDB ID 3pc8

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