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2hw3

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[[Image:2hw3.png|left|200px]]
 
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{{STRUCTURE_2hw3| PDB=2hw3 | SCENE= }}
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==T:O6-methyl-guanine pair in the polymerase postinsertion site (-1 basepair position)==
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<StructureSection load='2hw3' size='340' side='right'caption='[[2hw3]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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===T:O6-methyl-guanine pair in the polymerase postinsertion site (-1 basepair position)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2hw3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HW3 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17179038}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5-MONOPHOSPHATE'>6OG</scene>, <scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PRD_900003:sucrose'>PRD_900003</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hw3 OCA], [https://pdbe.org/2hw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hw3 RCSB], [https://www.ebi.ac.uk/pdbsum/2hw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hw3 ProSAT]</span></td></tr>
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[[2hw3]] is a 3 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HW3 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q45458_GEOSE Q45458_GEOSE] In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.[RuleBase:RU004460]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hw/2hw3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hw3 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA polymerase|DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:017179038</ref><references group="xtra"/>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
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[[Category: Beese, L S.]]
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[[Category: Large Structures]]
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[[Category: Forsberg, L J.]]
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[[Category: Beese LS]]
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[[Category: Warren, J J.]]
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[[Category: Forsberg LJ]]
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[[Category: Dna polymerase i]]
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[[Category: Warren JJ]]
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[[Category: Dna replication]]
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[[Category: Klenow fragment]]
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[[Category: O6-methyl-guanine]]
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[[Category: Protein-dna complex]]
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[[Category: Transferase-dna complex]]
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Current revision

T:O6-methyl-guanine pair in the polymerase postinsertion site (-1 basepair position)

PDB ID 2hw3

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