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1kke
From Proteopedia
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| - | [[Image:1kke.png|left|200px]] | ||
| - | + | ==Crystal Structure of Reovirus Attachment Protein Sigma1 Trimer== | |
| - | + | <StructureSection load='1kke' size='340' side='right'caption='[[1kke]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1kke]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_3_Dearing Mammalian orthoreovirus 3 Dearing]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KKE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kke OCA], [https://pdbe.org/1kke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kke RCSB], [https://www.ebi.ac.uk/pdbsum/1kke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kke ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1kke]] is a 3 chain structure | + | == Function == |
| + | [https://www.uniprot.org/uniprot/SIGM1_REOVD SIGM1_REOVD] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/1kke_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kke ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Hemagglutinin|Hemagglutinin]] | + | *[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]] |
| - | + | *[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | |
| - | + | __TOC__ | |
| - | < | + | </StructureSection> |
| - | [[Category: Mammalian orthoreovirus 3]] | + | [[Category: Large Structures]] |
| - | [[Category: Chappell | + | [[Category: Mammalian orthoreovirus 3 Dearing]] |
| - | [[Category: Dermody | + | [[Category: Chappell JD]] |
| - | [[Category: Prota | + | [[Category: Dermody TS]] |
| - | [[Category: Stehle | + | [[Category: Prota AE]] |
| - | + | [[Category: Stehle T]] | |
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Current revision
Crystal Structure of Reovirus Attachment Protein Sigma1 Trimer
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