3pka

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[[Image:3pka.png|left|200px]]
 
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{{STRUCTURE_3pka| PDB=3pka | SCENE= }}
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==M. tuberculosis MetAP with bengamide analog Y02, in Mn form==
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<StructureSection load='3pka' size='340' side='right'caption='[[3pka]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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===M. tuberculosis MetAP with bengamide analog Y02, in Mn form===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pka]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PKA FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21465667}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Y02:(2R,3R,4S,5R,6E)-3,4,5-TRIHYDROXY-2-METHOXY-8,8-DIMETHYL-N-[2-(2,4,6-TRIMETHYLPHENOXY)ETHYL]NON-6-ENAMIDE'>Y02</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pka OCA], [https://pdbe.org/3pka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pka RCSB], [https://www.ebi.ac.uk/pdbsum/3pka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pka ProSAT]</span></td></tr>
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[[3pka]] is a 1 chain structure of [[Aminopeptidase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKA OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAP12_MYCTU MAP12_MYCTU] Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.[HAMAP-Rule:MF_01974]<ref>PMID:19688379</ref> <ref>PMID:20038112</ref>
==See Also==
==See Also==
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*[[Aminopeptidase|Aminopeptidase]]
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021465667</ref><references group="xtra"/>
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__TOC__
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[[Category: Methionyl aminopeptidase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Lu, J P.]]
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[[Category: Lu JP]]
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[[Category: Ye, Q Z.]]
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[[Category: Ye QZ]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

M. tuberculosis MetAP with bengamide analog Y02, in Mn form

PDB ID 3pka

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