1nvm

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[[Image:1nvm.png|left|200px]]
 
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{{STRUCTURE_1nvm| PDB=1nvm | SCENE= }}
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==Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate==
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<StructureSection load='1nvm' size='340' side='right'caption='[[1nvm]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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===Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nvm]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_sp._CF600 Pseudomonas sp. CF600]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NVM FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12764229}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nvm OCA], [https://pdbe.org/1nvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nvm RCSB], [https://www.ebi.ac.uk/pdbsum/1nvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nvm ProSAT]</span></td></tr>
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[[1nvm]] is a 8 chain structure of [[Aldehyde dehydrogenase]] and [[Aldolase]] with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_sp. Pseudomonas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NVM OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HOA_PSEUF HOA_PSEUF] Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds such as phenols, cresols and catechols.[HAMAP-Rule:MF_01656]<ref>PMID:1732207</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nv/1nvm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nvm ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aldehyde dehydrogenase|Aldehyde dehydrogenase]]
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*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
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*[[Aldolase|Aldolase]]
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*[[Aldolase 3D structures|Aldolase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012764229</ref><references group="xtra"/>
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__TOC__
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[[Category: Pseudomonas sp.]]
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</StructureSection>
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[[Category: Manjasetty, A B.]]
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[[Category: Large Structures]]
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[[Category: Powlowski, J.]]
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[[Category: Pseudomonas sp. CF600]]
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[[Category: Vrielink, A.]]
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[[Category: Manjasetty AB]]
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[[Category: Bifunctional enzyme]]
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[[Category: Powlowski J]]
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[[Category: Lyase-oxidoreductase complex]]
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[[Category: Vrielink A]]
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[[Category: Sequestered tunnel]]
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[[Category: Substrate channeling]]
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Current revision

Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate

PDB ID 1nvm

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