3hx0

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[[Image:3hx0.png|left|200px]]
 
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{{STRUCTURE_3hx0| PDB=3hx0 | SCENE= }}
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==ternary complex of L277A, H511A, R514 mutant pol lambda bound to a 2 nucleotide gapped DNA substrate with a scrunched dA==
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<StructureSection load='3hx0' size='340' side='right'caption='[[3hx0]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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===ternary complex of L277A, H511A, R514 mutant pol lambda bound to a 2 nucleotide gapped DNA substrate with a scrunched dA===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3hx0]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HX0 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_019701199}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D3T:2,3-DIDEOXY-THYMIDINE-5-TRIPHOSPHATE'>D3T</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hx0 OCA], [https://pdbe.org/3hx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hx0 RCSB], [https://www.ebi.ac.uk/pdbsum/3hx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hx0 ProSAT]</span></td></tr>
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[[3hx0]] is a 16 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX0 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPOLL_HUMAN DPOLL_HUMAN] Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.<ref>PMID:11457865</ref> <ref>PMID:15537631</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/3hx0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hx0 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA polymerase|DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019701199</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bebenek, K.]]
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[[Category: Large Structures]]
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[[Category: Garcia-Diaz, M.]]
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[[Category: Bebenek K]]
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[[Category: Havener, J M.]]
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[[Category: Garcia-Diaz M]]
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[[Category: Krahn, J M.]]
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[[Category: Havener JM]]
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[[Category: Kunkel, T A.]]
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[[Category: Krahn JM]]
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[[Category: Larrea, A A.]]
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[[Category: Kunkel TA]]
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[[Category: Pedersen, L C.]]
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[[Category: Larrea AA]]
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[[Category: Perera, L.]]
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[[Category: Pedersen LC]]
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[[Category: Ramsden, D A.]]
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[[Category: Perera L]]
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[[Category: Dna damage]]
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[[Category: Ramsden DA]]
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[[Category: Dna repair]]
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[[Category: Dna replication]]
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[[Category: Dna synthesis]]
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[[Category: Dna-binding]]
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[[Category: Dna-directed dna polymerase]]
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[[Category: Lyase]]
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[[Category: Manganese]]
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[[Category: Metal-binding]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymerase lambda]]
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[[Category: Scrunch]]
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[[Category: Transferase]]
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[[Category: Transferase-dna complex]]
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[[Category: X-family]]
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Current revision

ternary complex of L277A, H511A, R514 mutant pol lambda bound to a 2 nucleotide gapped DNA substrate with a scrunched dA

PDB ID 3hx0

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