1t1n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1t1n" [edit=sysop:move=sysop])
Current revision (07:26, 30 October 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1t1n.png|left|200px]]
 
-
{{STRUCTURE_1t1n| PDB=1t1n | SCENE= }}
+
==CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN==
 +
<StructureSection load='1t1n' size='340' side='right'caption='[[1t1n]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1t1n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trematomus_newnesi Trematomus newnesi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T1N FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1n OCA], [https://pdbe.org/1t1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t1n RCSB], [https://www.ebi.ac.uk/pdbsum/1t1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t1n ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HBA1_TRENE HBA1_TRENE]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t1/1t1n_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t1n ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
As new structural data have become available, somewhat contrasting explanations of the Root effect in fish haemoglobins (Hb) have been provided. Hb 1 of the Antarctic fish Trematomus newnesi has a nearly pH-independent oxygen affinity, in spite of 95 % sequence identity with Hb 1 of Trematomus (previously named Pagothenia) bernacchii that has a strong Root effect. Here, the 2.2 A R-state structure of Trematomus newnesi Hb 1 is presented. The structure is similar to that of Root effect fish Hbs from Spot and T. bernacchii, suggesting that the differences in the pH dependence cannot be related to the modulation of the R-state. In comparison to T. bernacchii Hb 1, the role of the three mutations Thr41 (C6)alpha--&gt;Ile, Ala97 (G3)alpha--&gt;Ser and His41 (C7)beta--&gt;Tyr at the alpha1beta2-interface is discussed.
-
===CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN===
+
Crystal structure of Trematomus newnesi haemoglobin re-opens the root effect question.,Mazzarella L, D'Avino R, di Prisco G, Savino C, Vitagliano L, Moody PC, Zagari A J Mol Biol. 1999 Apr 16;287(5):897-906. PMID:10222199<ref>PMID:10222199</ref>
-
{{ABSTRACT_PUBMED_10222199}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 1t1n" style="background-color:#fffaf0;"></div>
-
[[1t1n]] is a 2 chain structure of [[Hemoglobin]] with sequence from [http://en.wikipedia.org/wiki/Trematomus_newnesi Trematomus newnesi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1N OCA].
+
==See Also==
==See Also==
-
*[[Hemoglobin|Hemoglobin]]
+
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:010222199</ref><ref group="xtra">PMID:010737936</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Trematomus newnesi]]
[[Category: Trematomus newnesi]]
-
[[Category: Mazzarella, L.]]
+
[[Category: Mazzarella L]]
-
[[Category: Savino, C.]]
+
[[Category: Savino C]]
-
[[Category: Vitagliano, L.]]
+
[[Category: Vitagliano L]]
-
[[Category: Zagari, A.]]
+
[[Category: Zagari A]]
-
[[Category: Hemoglobin]]
+
-
[[Category: Oxygen transport]]
+

Current revision

CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN

PDB ID 1t1n

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1t1n"
Personal tools