1wug

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[[Image:1wug.png|left|200px]]
 
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{{STRUCTURE_1wug| PDB=1wug | SCENE= }}
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==complex structure of PCAF bromodomain with small chemical ligand NP1==
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<StructureSection load='1wug' size='340' side='right'caption='[[1wug]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1wug]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WUG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NP1:N-(3-AMINOPROPYL)-4-METHYL-2-NITROBENZENAMINE'>NP1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wug OCA], [https://pdbe.org/1wug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wug RCSB], [https://www.ebi.ac.uk/pdbsum/1wug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wug ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAT2B_HUMAN KAT2B_HUMAN] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:8684459</ref> <ref>PMID:9707565</ref> <ref>PMID:10675335</ref> <ref>PMID:23932781</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/1wug_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wug ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Development of drug resistance from mutations in the targeted viral proteins leads to continuation of viral production by chronically infected cells, contributing to HIV-mediated immune dysfunction. Targeting a host cell protein essential for viral reproduction, rather than a viral protein, may minimize the viral drug resistance problem as observed with HIV protease inhibitors. We report here the development of a novel class of N1-aryl-propane-1,3-diamine compounds using a structure-based approach that selectively inhibit the activity of the bromodomain of the human transcriptional co-activator PCAF, of which association with the HIV trans-activator Tat is essential for transcription and replication of the integrated HIV provirus.
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===complex structure of PCAF bromodomain with small chemical ligand NP1===
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Selective small molecules blocking HIV-1 Tat and coactivator PCAF association.,Zeng L, Li J, Muller M, Yan S, Mujtaba S, Pan C, Wang Z, Zhou MM J Am Chem Soc. 2005 Mar 2;127(8):2376-7. PMID:15724976<ref>PMID:15724976</ref>
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{{ABSTRACT_PUBMED_15724976}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1wug" style="background-color:#fffaf0;"></div>
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[[1wug]] is a 1 chain structure of [[Histone acetyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUG OCA].
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==See Also==
==See Also==
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*[[Histone acetyltransferase|Histone acetyltransferase]]
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*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015724976</ref><references group="xtra"/>
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__TOC__
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[[Category: Histone acetyltransferase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Li, J.]]
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[[Category: Large Structures]]
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[[Category: Mujtaba, S.]]
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[[Category: Li J]]
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[[Category: Muller, M.]]
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[[Category: Mujtaba S]]
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[[Category: Pan, C.]]
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[[Category: Muller M]]
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[[Category: Wang, Z.]]
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[[Category: Pan C]]
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[[Category: Yan, S.]]
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[[Category: Wang Z]]
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[[Category: Zeng, L.]]
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[[Category: Yan S]]
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[[Category: Zhou, M M.]]
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[[Category: Zeng L]]
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[[Category: Bromodomain]]
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[[Category: Zhou MM]]
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[[Category: Chemical ligand]]
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[[Category: Histone-acetyltransferase]]
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[[Category: Nmr-structure]]
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[[Category: Transferase]]
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Current revision

complex structure of PCAF bromodomain with small chemical ligand NP1

PDB ID 1wug

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