1y0v
From Proteopedia
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| - | [[Image:1y0v.png|left|200px]] | ||
| - | + | ==Crystal structure of anthrax edema factor (EF) in complex with calmodulin and pyrophosphate== | |
| - | + | <StructureSection load='1y0v' size='340' side='right'caption='[[1y0v]], [[Resolution|resolution]] 3.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1y0v]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y0V FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0v OCA], [https://pdbe.org/1y0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y0v RCSB], [https://www.ebi.ac.uk/pdbsum/1y0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y0v ProSAT]</span></td></tr> |
| - | [[1y0v]] | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CYAA_BACAN CYAA_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. EF is a calmodulin-dependent adenylyl cyclase that, when associated with PA, causes edema. EF is not toxic by itself and it is required for the survival of germinated spores within macrophages at the early stages of infection. Provokes dramatic elevation of intracellular cAMP levels in the host. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y0/1y0v_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y0v ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | + | *[[Calmodulin 3D structures|Calmodulin 3D structures]] | |
| - | *[[Calmodulin|Calmodulin]] | + | __TOC__ |
| - | + | </StructureSection> | |
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[[Category: Bacillus anthracis]] | [[Category: Bacillus anthracis]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Xenopus laevis]] | [[Category: Xenopus laevis]] | ||
| - | [[Category: Florian | + | [[Category: Florian J]] |
| - | [[Category: Guo | + | [[Category: Guo Q]] |
| - | [[Category: Shen | + | [[Category: Shen Y]] |
| - | [[Category: Tang | + | [[Category: Tang W-J]] |
| - | [[Category: Zhukovskaya | + | [[Category: Zhukovskaya NL]] |
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Current revision
Crystal structure of anthrax edema factor (EF) in complex with calmodulin and pyrophosphate
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