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1l2h

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[[Image:1l2h.png|left|200px]]
 
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{{STRUCTURE_1l2h| PDB=1l2h | SCENE= }}
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==Crystal structure of Interleukin 1-beta F42W/W120F mutant==
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<StructureSection load='1l2h' size='340' side='right'caption='[[1l2h]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
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===Crystal structure of Interleukin 1-beta F42W/W120F mutant===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1l2h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2H FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12554939}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2h OCA], [https://pdbe.org/1l2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2h RCSB], [https://www.ebi.ac.uk/pdbsum/1l2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2h ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1l2h]] is a 1 chain structure of [[Interleukin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2H OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l2h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l2h ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Interleukin|Interleukin]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012554939</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Heidary, D K.]]
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[[Category: Large Structures]]
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[[Category: Jennings, P A.]]
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[[Category: Heidary DK]]
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[[Category: Kelker, M S.]]
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[[Category: Jennings PA]]
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[[Category: Oseroff, V.]]
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[[Category: Kelker MS]]
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[[Category: Rudolph, M G.]]
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[[Category: Oseroff V]]
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[[Category: Schneider, T R.]]
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[[Category: Rudolph MG]]
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[[Category: Wilson, I A.]]
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[[Category: Schneider TR]]
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[[Category: Yeates, T O.]]
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[[Category: Wilson IA]]
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[[Category: Beta-trefoil]]
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[[Category: Yeates TO]]
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[[Category: F42w/w120f double mutant]]
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[[Category: Hemihedral twinning]]
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[[Category: Immune system]]
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[[Category: Interleukin-1 beta]]
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[[Category: Mad phasing]]
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[[Category: Protein folding]]
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Current revision

Crystal structure of Interleukin 1-beta F42W/W120F mutant

PDB ID 1l2h

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