This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3hyy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:27, 20 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3hyy.png|left|200px]]
 
-
{{STRUCTURE_3hyy| PDB=3hyy | SCENE= }}
+
==Crystal structure of Hsp90 with fragment 37-D04==
-
 
+
<StructureSection load='3hyy' size='340' side='right'caption='[[3hyy]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
===Crystal structure of Hsp90 with fragment 37-D04===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3hyy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HYY FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
==About this Structure==
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=37D:METHYL+5-FURAN-2-YL-3-METHYL-1H-PYRAZOLE-4-CARBOXYLATE'>37D</scene></td></tr>
-
[[3hyy]] is a 1 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HYY OCA].
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hyy OCA], [https://pdbe.org/3hyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hyy RCSB], [https://www.ebi.ac.uk/pdbsum/3hyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hyy ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/3hyy_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hyy ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Heat Shock Proteins|Heat Shock Proteins]]
+
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Barker, J.]]
+
[[Category: Large Structures]]
-
[[Category: Cheng, R K.Y.]]
+
[[Category: Barker J]]
-
[[Category: Felicetti, B.]]
+
[[Category: Cheng RKY]]
-
[[Category: Mather, O.]]
+
[[Category: Felicetti B]]
-
[[Category: Palan, S.]]
+
[[Category: Mather O]]
-
[[Category: Whittaker, M.]]
+
[[Category: Palan S]]
-
[[Category: Atp-binding]]
+
[[Category: Whittaker M]]
-
[[Category: Chaperone]]
+
-
[[Category: Nucleotide binding]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Stress response]]
+

Current revision

Crystal structure of Hsp90 with fragment 37-D04

PDB ID 3hyy

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3hyy"
Personal tools