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1ju6

From Proteopedia

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[[Image:1ju6.png|left|200px]]
 
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{{STRUCTURE_1ju6| PDB=1ju6 | SCENE= }}
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==Human Thymidylate Synthase Complex with dUMP and LY231514, A Pyrrolo(2,3-d)pyrimidine-based Antifolate==
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<StructureSection load='1ju6' size='340' side='right'caption='[[1ju6]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
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===Human Thymidylate Synthase Complex with dUMP and LY231514, A Pyrrolo(2,3-d)pyrimidine-based Antifolate===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ju6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JU6 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11697906}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.89&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LYA:2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC+ACID'>LYA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ju6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ju6 OCA], [https://pdbe.org/1ju6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ju6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ju6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ju6 ProSAT]</span></td></tr>
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[[1ju6]] is a 4 chain structure of [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU6 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/1ju6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ju6 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Thymidylate synthase|Thymidylate synthase]]
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011697906</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Thymidylate synthase]]
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[[Category: Large Structures]]
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[[Category: Biermann, D.]]
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[[Category: Biermann D]]
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[[Category: Finer-Moore, J S.]]
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[[Category: Finer-Moore JS]]
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[[Category: Fritz, T A.]]
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[[Category: Fritz TA]]
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[[Category: Gates, S B.]]
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[[Category: Gates SB]]
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[[Category: MacKellar, W C.]]
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[[Category: MacKellar WC]]
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[[Category: Patel, V F.]]
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[[Category: Patel VF]]
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[[Category: Sayre, P H.]]
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[[Category: Sayre PH]]
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[[Category: Stroud, R M.]]
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[[Category: Stroud RM]]
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[[Category: Antifolate]]
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[[Category: Cancer]]
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[[Category: Drug resistance]]
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[[Category: Dtmp synthesis]]
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[[Category: Transferase]]
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Current revision

Human Thymidylate Synthase Complex with dUMP and LY231514, A Pyrrolo(2,3-d)pyrimidine-based Antifolate

PDB ID 1ju6

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