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3f3y

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[[Image:3f3y.png|left|200px]]
 
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{{STRUCTURE_3f3y| PDB=3f3y | SCENE= }}
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==Crystal structure of human cytosolic sulfotransferase SULT2A1 in complex with PAP and lithocholic acid==
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<StructureSection load='3f3y' size='340' side='right'caption='[[3f3y]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Crystal structure of human cytosolic sulfotransferase SULT2A1 in complex with PAP and lithocholic acid===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3f3y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F3Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4OA:(3BETA,5BETA,14BETA,17ALPHA)-3-HYDROXYCHOLAN-24-OIC+ACID'>4OA</scene>, <scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
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[[3f3y]] is a 4 chain structure of [[Sulfotransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F3Y OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f3y OCA], [https://pdbe.org/3f3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f3y RCSB], [https://www.ebi.ac.uk/pdbsum/3f3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f3y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ST2A1_HUMAN ST2A1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f3/3f3y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f3y ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Sulfotransferase|Sulfotransferase]]
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*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
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[[Category: Bile-salt sulfotransferase]]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Amaya, M.]]
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[[Category: Large Structures]]
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[[Category: Dong, A.]]
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[[Category: Amaya M]]
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[[Category: Edwards, A M.]]
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[[Category: Dong A]]
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[[Category: Pan, P W.]]
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[[Category: Edwards AM]]
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[[Category: Bile acid catabolism]]
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[[Category: Pan PW]]
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[[Category: Human cytosolic sulfotransferase]]
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[[Category: Lipid metabolism]]
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[[Category: Lithocholic acid]]
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[[Category: Pap]]
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[[Category: Steroid metabolism]]
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[[Category: Sult2a1]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human cytosolic sulfotransferase SULT2A1 in complex with PAP and lithocholic acid

PDB ID 3f3y

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