1mj9

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[[Image:1mj9.png|left|200px]]
 
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{{STRUCTURE_1mj9| PDB=1mj9 | SCENE= }}
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==Crystal structure of yeast Esa1(C304S) mutant complexed with Coenzyme A==
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<StructureSection load='1mj9' size='340' side='right'caption='[[1mj9]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal structure of yeast Esa1(C304S) mutant complexed with Coenzyme A===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MJ9 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12368900}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mj9 OCA], [https://pdbe.org/1mj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mj9 RCSB], [https://www.ebi.ac.uk/pdbsum/1mj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mj9 ProSAT]</span></td></tr>
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[[1mj9]] is a 1 chain structure of [[Histone acetyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MJ9 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ESA1_YEAST ESA1_YEAST] Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, histone H2A to form H2AK4ac and H2AK7ac, and histone variant H2A.Z to form H2A.ZK14ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me.<ref>PMID:9858608</ref> <ref>PMID:10082517</ref> <ref>PMID:10835360</ref> <ref>PMID:10911987</ref> <ref>PMID:12353039</ref> <ref>PMID:15175650</ref> <ref>PMID:15494307</ref> <ref>PMID:15045029</ref> <ref>PMID:15923609</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mj/1mj9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mj9 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Histone acetyltransferase|Histone acetyltransferase]]
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*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012368900</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Harper, S.]]
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[[Category: Harper S]]
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[[Category: Marmorstein, R.]]
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[[Category: Marmorstein R]]
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[[Category: Speicher, D.]]
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[[Category: Speicher D]]
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[[Category: Yan, Y.]]
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[[Category: Yan Y]]
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[[Category: Esa1]]
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[[Category: Hat]]
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[[Category: Histone acetyltransferase]]
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[[Category: Myst]]
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[[Category: Transferase]]
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Current revision

Crystal structure of yeast Esa1(C304S) mutant complexed with Coenzyme A

PDB ID 1mj9

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