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1j8r

From Proteopedia

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[[Image:1j8r.png|left|200px]]
 
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{{STRUCTURE_1j8r| PDB=1j8r | SCENE= }}
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==BINARY COMPLEX OF THE PAPG RECEPTOR-BINDING DOMAIN BOUND TO GBO4 RECEPTOR==
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<StructureSection load='1j8r' size='340' side='right'caption='[[1j8r]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===BINARY COMPLEX OF THE PAPG RECEPTOR-BINDING DOMAIN BOUND TO GBO4 RECEPTOR===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1j8r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J8R FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11440716}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j8r OCA], [https://pdbe.org/1j8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j8r RCSB], [https://www.ebi.ac.uk/pdbsum/1j8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j8r ProSAT], [https://www.topsan.org/Proteins/MCSG/1j8r TOPSAN]</span></td></tr>
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[[1j8r]] is a 1 chain structure of [[PapG receptor]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J8R OCA].
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</table>
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== Function ==
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==See Also==
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[https://www.uniprot.org/uniprot/PAPG2_ECOLX PAPG2_ECOLX] Tip adhesin component of type P pili that plays a critical role in kidney infection through targeted interaction with the globoseries glycolipids containing the Gal-alpha(1-4)-Gal disaccharide present on uroepithelial cells (PubMed:11440716, PubMed:31361021). In turn, transcriptionally regulates host gene expression in kidney cells, leading to inflammatory pathway activation and renal tissue damage. Acts thereby as key determinant of invasive uropathogenic E.coli (UPEC), which cause pyelonephritis and urinary-source bacteremia (By similarity).[UniProtKB:A0A0H2VAQ6]<ref>PMID:11440716</ref> <ref>PMID:31361021</ref>
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*[[PapG receptor|PapG receptor]]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Reference==
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Check<jmol>
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<ref group="xtra">PMID:011440716</ref><references group="xtra"/>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/1j8r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j8r ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Dodson, K W.]]
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[[Category: Large Structures]]
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[[Category: Hultgren, S J.]]
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[[Category: Dodson KW]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Hultgren SJ]]
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[[Category: Magnusson, G.]]
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[[Category: Magnusson G]]
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[[Category: Pinkner, J S.]]
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[[Category: Pinkner JS]]
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[[Category: Rose, T.]]
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[[Category: Rose T]]
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[[Category: Waksman, G.]]
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[[Category: Waksman G]]
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[[Category: Gbo4]]
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[[Category: Mcsg]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Pag adhesin]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Structural protein]]
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Current revision

BINARY COMPLEX OF THE PAPG RECEPTOR-BINDING DOMAIN BOUND TO GBO4 RECEPTOR

PDB ID 1j8r

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