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1fgl

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[[Image:1fgl.png|left|200px]]
 
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{{STRUCTURE_1fgl| PDB=1fgl | SCENE= }}
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==Cyclophilin A complexed with a fragment of HIV-1 GAG protein==
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<StructureSection load='1fgl' size='340' side='right'caption='[[1fgl]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===Cyclophilin A complexed with a fragment of HIV-1 GAG protein===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1fgl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(WMJ2_ISOLATE) Human immunodeficiency virus type 1 (WMJ2 ISOLATE)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FGL FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9016720}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAL:BETA-ALANINE'>BAL</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fgl OCA], [https://pdbe.org/1fgl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fgl RCSB], [https://www.ebi.ac.uk/pdbsum/1fgl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fgl ProSAT]</span></td></tr>
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[[1fgl]] is a 2 chain structure of [[Cyclophilin]] and [[Gag polyprotein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FGL OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fg/1fgl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fgl ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cyclophilin|Cyclophilin]]
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*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
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*[[Gag polyprotein|Gag polyprotein]]
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*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:009016720</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Human immunodeficiency virus 1]]
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[[Category: Large Structures]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Chen Y]]
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[[Category: Chen, Y.]]
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[[Category: Fischer G]]
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[[Category: Fischer, G.]]
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[[Category: Ke H]]
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[[Category: Ke, H.]]
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[[Category: Schutkowski M]]
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[[Category: Schutkowski, M.]]
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[[Category: Zhao Y]]
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[[Category: Zhao, Y.]]
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[[Category: Aid]]
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[[Category: Binding protein for cyclosporin some]]
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[[Category: Cyclophilin]]
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[[Category: Isomerase-peptide complex]]
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[[Category: Isomerase-viral protein complex]]
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Current revision

Cyclophilin A complexed with a fragment of HIV-1 GAG protein

PDB ID 1fgl

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