1yye

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1yye" [edit=sysop:move=sysop])
Current revision (09:01, 14 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1yye.png|left|200px]]
 
-
{{STRUCTURE_1yye| PDB=1yye | SCENE= }}
+
==Crystal structure of estrogen receptor beta complexed with way-202196==
-
 
+
<StructureSection load='1yye' size='340' side='right'caption='[[1yye]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
-
===Crystal structure of estrogen receptor beta complexed with way-202196===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1yye]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YYE FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_15943471}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=196:3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE'>196</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yye OCA], [https://pdbe.org/1yye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yye RCSB], [https://www.ebi.ac.uk/pdbsum/1yye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yye ProSAT]</span></td></tr>
-
[[1yye]] is a 4 chain structure of [[Estrogen receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YYE OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yy/1yye_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yye ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Estrogen receptor|Estrogen receptor]]
+
*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:015943471</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Edsall, R J.]]
+
[[Category: Large Structures]]
-
[[Category: Harris, H A.]]
+
[[Category: Edsall Jr RJ]]
-
[[Category: Henderson, R A.]]
+
[[Category: Harris HA]]
-
[[Category: Keith, J C.]]
+
[[Category: Henderson RA]]
-
[[Category: Manas, E S.]]
+
[[Category: Keith Jr JC]]
-
[[Category: Mewshaw, R E.]]
+
[[Category: Manas ES]]
-
[[Category: Xu, Z B.]]
+
[[Category: Mewshaw RE]]
-
[[Category: Yang, C.]]
+
[[Category: Xu ZB]]
-
[[Category: Agonist]]
+
[[Category: Yang C]]
-
[[Category: Er]]
+
-
[[Category: Er-beta]]
+
-
[[Category: Estrogen]]
+
-
[[Category: Estrogen receptor]]
+
-
[[Category: Estrogen receptor beta]]
+
-
[[Category: Nuclear receptor]]
+
-
[[Category: Transcription]]
+
-
[[Category: Transcription factor]]
+

Current revision

Crystal structure of estrogen receptor beta complexed with way-202196

PDB ID 1yye

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1yye"
Personal tools